Cell-Type-Specific Activity in Prefrontal Cortex during Goal-Directed Behavior.
Cell-Type-Specific Activity in Prefrontal Cortex during Goal-Directed Behavior.
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DOI：
10.1016/j.neuron.2015.06.021
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发表时间：
2015-07-15
期刊：
影响因子：
16.2
通讯作者：
Dan Y
中科院分区：
文献类型：
--
作者：
Pinto L;Dan Y
前额叶皮层（PFC）在控制目标导向行为中起着关键作用。尽管在PFC中观察到了各种与任务相关的信号，但它们是否由不同类型的细胞差异编码仍不清楚。在这里，我们进行了细胞分辨率显微内窥镜Ca2+成像从遗传定义的细胞类型在背内侧PFC的小鼠执行PFC依赖的感觉辨别任务。我们发现，相同亚型的抑制性中间神经元彼此相似，但不同亚型的优先信号不同的任务相关的事件：生长抑素阳性神经元主要信号运动动作（舔），血管活性肠肽阳性神经元强烈反应的行动结果，而小清蛋白阳性神经元的选择性较低，响应感觉线索，运动动作，和审判结果。与每个中间神经元亚型相比，锥体神经元表现出更大的功能异质性，并且它们的反应在皮层各层之间变化。这种细胞类型和层状神经元功能特性的差异可能是至关重要的PFC微电路内的本地计算。
The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types remains unclear. Here we performed cellular-resolution microendoscopic Ca2+ imaging from genetically defined cell types in the dorsomedial PFC of mice performing a PFC-dependent sensory discrimination task. We found that inhibitory interneurons of the same subtype were similar to each other, but different subtypes preferentially signaled different task-related events: somatostatin-positive neurons primarily signaled motor action (licking), vasoactive intestinal peptide-positive neurons responded strongly to action outcomes, whereas parvalbumin-positive neurons were less selective, responding to sensory cues, motor action, and trial outcomes. Compared to each interneuron subtype, pyramidal neurons showed much greater functional heterogeneity, and their responses varied across cortical layers. Such cell-type and laminar differences in neuronal functional properties may be crucial for local computation within the PFC microcircuit.