Bioactive silica nanoparticles reverse age-associated bone loss in mice.
Bioactive silica nanoparticles reverse age-associated bone loss in mice.
复制标题
生物活性二氧化硅纳米粒子可逆转小鼠与年龄相关的骨质流失。
DOI：
10.1016/j.nano.2015.01.013
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
BeckJr,GeorgeR
中科院分区：
文献类型：
--
作者：
Weitzmann,MNeale;Ha,Shin-Woo;Vikulina,Tatyana;Roser-Page,Susanne;Lee,Jin-Kyu;BeckJr,GeorgeR
我们最近报道，在体外，工程50纳米球形二氧化硅纳米粒子促进骨建设成骨细胞的分化和活动，但抑制骨吸收破骨细胞。此外，这些纳米颗粒在体内促进幼龄小鼠的骨生长。我们现在已经研究了这些纳米颗粒逆转老年小鼠（人类老年性骨质疏松症模型）骨丢失的能力。老年小鼠每周接受纳米颗粒，并对骨矿物质密度（BMD）、骨结构和骨转换进行定量。我们的数据显示BMD、骨体积和骨形成的生化标志物显著增加。生物化学和组织学检查未能确定纳米颗粒给药引起的任何异常。我们的研究表明，二氧化硅纳米颗粒通过促进骨形成的机制有效地钝和逆转小鼠中与年龄相关的骨丢失。这些数据表明，成骨二氧化硅纳米颗粒可能是一种安全有效的治疗方法，用于抵消年龄相关的骨丢失。基于他们以前的体外研究结果，作者小组研究了球形二氧化硅纳米颗粒在骨质疏松症小鼠模型中逆转骨丢失的作用。结果表明，腹腔注射二氧化硅纳米颗粒可以增加骨密度，几乎没有观察到毒副作用。这种新方法可能在未来治疗骨质疏松症中发挥重要作用。
We recently reported thatin vitro, engineered 50 nm spherical silica nanoparticles promote the differentiation and activity of bone building osteoblasts but suppress bone-resorbing osteoclasts. Furthermore, these nanoparticles promote bone accretion in young micein vivo. We have now investigated the capacity of these nanoparticles to reverse bone loss in aged mice, a model of human senile osteoporosis. Aged mice received nanoparticles weekly and bone mineral density (BMD), bone structure, and bone turnover were quantified. Our data revealed a significant increase in BMD, bone volume, and biochemical markers of bone formation. Biochemical and histological examinations failed to identify any abnormalities caused by nanoparticle administration. Our studies demonstrate that silica nanoparticles effectively blunt and reverse age-associated bone loss in mice by a mechanism involving promotion of bone formation. The data suggest that osteogenic silica nanoparticles may be a safe and effective therapeutic for counteracting age-associated bone loss.From the Clinical EditorOsteoporosis poses a significant problem in the society. Based on their previous in-vitro findings, the authors' group investigated the effects of spherical silica nanoparticles in reversing bone loss in a mouse model of osteoporosis. The results showed that intra-peritoneal injections of silica nanoparticles could increase bone mineral density, with little observed toxic side effects. This novel method may prove important in future therapy for combating osteoporosis.