Variables that influence cellular uptake and cytotoxic/cytoprotective effects of macrocyclic iron complexes.
Variables that influence cellular uptake and cytotoxic/cytoprotective effects of macrocyclic iron complexes.
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DOI：
10.1021/ic202204u
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发表时间：
2012-01
影响因子：
4.6
通讯作者：
A. Haber;M. Aviram;Z. Gross
中科院分区：
文献类型：
--
作者：
A. Haber;M. Aviram;Z. Gross
通过一个简单的方法，伴随着细胞活力测试的基础和诱导的氧化应激下的大环铁（III）络合物的细胞摄取的测定，表明对细胞内氧化应激的保护需要合理的高内化和有利的抗/促氧化剂的配置文件。在四个测试的复合物，只有双极性铁（III）corrole符合这些标准。
Determination of the cellular uptake of macrocyclic iron(III) complexes by a facile method, accompanied by cell viability tests under both basal and induced oxidative stress, demonstrates that protection against intracellular oxidative stress requires reasonably high internalization and favorable anti/prooxidant profiles. Of the four tested complexes, only amphipolar iron(III) corrole met these criteria.