Postnatal lung function in lambs after fetal hormone treatment. Effects of gestational age.
Postnatal lung function in lambs after fetal hormone treatment. Effects of gestational age.
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胎儿激素治疗后羔羊的产后肺功能。
DOI：
10.1164/ajrccm.152.4.7551379
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Kelly,R
中科院分区：
文献类型：
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作者：
Ikegami,M;Polk,DH;Jobe,AH;Newnham,J;Sly,P;Kohen,R;Kelly,R
我们之前发现，在妊娠128 d的早产前48小时肌肉注射倍他米松与甲状腺素联合单剂量倍他米松可改善胎羊的产后肺功能。我们现在想知道0.5 mg/kg倍他米松和15微克/kg T4单胎肌内注射如何改变妊娠121和135 d治疗后48小时肺反应。妊娠121 d时，胎儿激素治疗显著改善了产后肺功能。依从性提高了55%，动脉PO2从39上升到215 mm Hg， PCO2从109下降到79 mm Hg，最大肺容量增加了112%。激素治疗降低了呼吸衰竭的严重程度，尽管这些非常早产的羔羊仍然有严重的呼吸衰竭。在妊娠135 d时，胎儿激素治疗降低了使PCO2值从30到21 cm H2O正常化所需的通气压力要求。依从性增加了40%，最大肺容量增加了33%。妊娠135 d时，激素治疗对肺泡或肺组织、饱和磷脂酰胆碱或肺泡SP-A池大小没有影响。我们得出结论，胎儿激素治疗显著改善了两个胎龄的产后肺功能，尽管反应的特征不同。
We previously found that a single dose of betamethasone in combination with thyroxine given by intramuscular injection to fetal sheep 48 h before preterm delivery at 128 d gestation improved postnatal lung function. We have now asked how the combination of 0.5 mg/kg betamethasone and 15 micrograms/kg T4 given by a single fetal intramuscular injection changes lung response 48 h after treatment at 121 and 135 d gestation. At 121 d gestation the fetal hormone treatment significantly improved postnatal lung function. Compliance increased by 55%, arterial PO2 increased from 39 to 215 mm Hg, PCO2 decreased from 109 to 79 mm Hg, and maximal lung volumes increased by 112%. The hormone treatment decreased the severity of the respiratory failure, although these very preterm lambs still had severe respiratory failure. At 135 d gestation, the fetal hormone treatment decreased the ventilatory pressure requirements that were needed to normalize PCO2 values from 30 to 21 cm H2O. Compliance increased by 40%, and maximal lung volumes increased by 33%. Alveolar or lung tissue, saturated phosphatidylcholine, or alveolar SP-A pool sizes did not change with hormone treatment at 135 d gestation. We conclude that fetal hormone treatment significantly improved postnatal lung function at both gestational ages, although the characteristics of the responses were different.