THE DEMONSTRATION OF RECURRENT DEMYELINATION AND REMYELINATION OF AXONS IN THE CENTRAL NERVOUS-SYSTEM
THE DEMONSTRATION OF RECURRENT DEMYELINATION AND REMYELINATION OF AXONS IN THE CENTRAL NERVOUS-SYSTEM
复制标题
中枢神经系统轴突反复脱髓鞘和再髓鞘化的证明
DOI：
10.1007/bf00689988
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发表时间：
1981-01-01
影响因子：
12.7
通讯作者：
LUDWIN, SK
中科院分区：
文献类型：
--
作者：
JOHNSON, ES;LUDWIN, SK
通过对小鼠重复给予Cuprizone [双环己酮双二腙]，建立了研究CNS中复发性脱髓鞘和髓鞘再生的模型。与Cuprizone第1个疗程期间观察到的脱髓鞘相反，复发性脱髓鞘明显延长，表现出回染性胶质病变的特征，并导致炎症和胶质反应大大减少。重复髓鞘再生也发生在一个较慢的克里思，变化显着的完整性，并与少突胶质细胞再生减少。如果有少突胶质细胞，该模型中中央中枢神经系统的轴突可以反复髓鞘再生。少突胶质细胞的再生依赖于组织对脱髓鞘的反应，并且有髓鞘的轴突并不比正常轴突更容易发生脱髓鞘。
A model for studying recurrent demyelination and remyelination in the CNS was developed by repeated administration of Cuprizone [biscyelohexanone oxaldihydrazone] to mice. In contrast to the demyelination seen during the 1st course of Cuprizone, the recurrent demyelination was markedly protracted, displayed features of a dying-back gliopathy, and resulted in a greatly reduced inflammatory and glial reaction. The repeat remyelination also occurred at a slower tempo, varied markedly in completeness, and was associated with a diminished regeneration of oligodendrocytes. Axons of the central CNS in this model can be recurrently remyelinated if oligodendrocytes are available. Regeneration of oligodendrocytes is dependent upon the tissue reaction to demyelination, and remyelinated axons are not more susceptible to demyelination than normal ones.