A biointerface effect on the self-assembly of ribonucleic acids: a possible mechanism of RNA polymerisation in the self-replication cycle
A biointerface effect on the self-assembly of ribonucleic acids: a possible mechanism of RNA polymerisation in the self-replication cycle
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DOI：
10.1039/c9nr09537c
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发表时间：
2020-03-28
期刊：
影响因子：
6.7
通讯作者：
Yasuoka, Kenji
中科院分区：
文献类型：
--
作者：
Arai, Noriyoshi;Kobayashi, Yusei;Yasuoka, Kenji
尽管经过了几十年的深入研究，关于地球上第一批细胞的形成和生长仍然存在许多问题。在这里，我们使用计算机模拟比较了核糖核酸在两种环境中的自组装过程：封闭在囊泡细胞膜和散装环境中。发现在前一种环境下，自组装更有利，并确定了这种生物界面效应的起源。这些结果将有助于更好地了解原始地球上生命的起源。
Despite decades of intensive research, many questions remain on the formation and growth of the first cells on Earth. Here, we used computer simulation to compare the self-assembly process of ribonucleic acids in two environments: enclosed in a vesicle-cell membrane and in the bulk. The self-assembly was found to be more favoured in the former environment, and the origin of such a biointerface effect was identified. These results will contribute to a better understanding of the origin of life on the primitive Earth.