A simulation study to evaluate the impact of the number of lesions measured on response assessment.
A simulation study to evaluate the impact of the number of lesions measured on response assessment.
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DOI：
10.1016/j.ejca.2008.11.010
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发表时间：
2009-01
影响因子：
8.4
通讯作者：
Goenen, Mithat
中科院分区：
文献类型：
--
作者：
Moskowitz, Chaya S.;Jia, Xiaoyu;Schwartz, Lawrence H.;Goenen, Mithat
关键词：
The objectives of this study were to evaluate whether the number of lesions that are used to measure tumor burden affects response assessment and inter-rater variability. In order to accomplish this, a simulation study was conducted. Data were generated from a mixed-effects mixture model. Parameter values to input in the model were obtained from analysis of real data. Response assessments based on ten, five, three, two, and one lesion were evaluated. There was little difference between response assessments based on five lesions and response assessments based on ten lesions. When fewer than five lesions were used to assess response, there were notable differences from the ten-lesion based response assessment. Basing response assessment on a small number of lesions tends to overestimate response rates and lead to misclassification of patients’ response status. Therefore, measuring five lesions per patient appears to sufficiently capture patients’ response to therapy. Measuring fewer than five lesions results in loss of information that may adversely affect clinical trial results as well as patient management.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
影响因子：
5
作者：
Hopper, KD;Kasales, CJ;Jozefiak, JA
通讯作者：
Jozefiak, JA
影响因子：
10.3
作者：
Karrison, Theodore G.;Maitland, Michael L.;Ratain, Mark J.
通讯作者：
Ratain, Mark J.
DOI：
10.1093/jnci/92.3.205
发表时间：
2000-02-02
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Therasse, P;Arbuck, SG;Gwyther, SG
通讯作者：
Gwyther, SG
DOI：
10.1016/0197-2456(89)90015-9
发表时间：
1989-03-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
SIMON, R
通讯作者：
SIMON, R