Factors affecting the survival of patients with oesophageal carcinoma under radiotherapy in the north of Iran
Factors affecting the survival of patients with oesophageal carcinoma under radiotherapy in the north of Iran
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DOI：
10.1054/bjoc.2001.2153
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发表时间：
2001-11-30
影响因子：
8.8
通讯作者：
Hajian-Tilaki, KO
中科院分区：
文献类型：
--
作者：
Hajian-Tilaki, KO
在发病率高的伊朗北方，研究了与食管癌患者放疗后生存有关的因素。我们使用历史队列和食管癌患者病历信息进行了一项分析研究。在1992年至1996年期间转诊到巴布尔萨尔Shahid Rajaii放射治疗中心的523名患者中，我们跟踪了1998年有地址的230名患者。未接触者的预后因素频率与研究中包含的因素非常相似。采用Kaplan-Meier非参数生存分析法和考克斯回归模型对数据进行分析，以确定预后因素的风险比（FIR），诊断后1年生存率为42%，2年生存率为21%，5年生存率为8%。年龄在50-64岁之间的患者生存率低于年龄小于50岁的患者（RR = 1.73，P = 0.03）;年龄大于或接近65岁的患者的风险比为1.88（P = 0.03）。女性生存率明显高于男性（RR = 0.71，P = 0.02）。放射治疗剂量每增加100 rads，危险比显著降低1%（RR = 0.99，P = 0.05）;每一次放疗，风险比显著降低4%（RR = 0.96，P = 0.0001）;在放射治疗下，每平方厘米表面尺寸的风险比显著增加（RR = 1，002，P = 0.04）。我们没有观察到组织学、道岔解剖位置或治疗类型对生存率的显著差异（P > 0.05）。预后极差。0 2001年癌症研究运动。
Factors relevant to the survival of patients with oesophageal cancer under radiotherapy have been studied in northern Iran where its incidence is high. We conducted an analytical study using a historical cohort and information from the medical charts of patients with oesophageal cancer. Out of 523 patients referred to the Shahid Rajaii radiotherapy centre in Babolsar from 1992 to 1996, we followed 230 patients for whom an address was available in 1998. The frequency of prognostic factors among those not contacted was very similar to those included in the study. The data were analysed using survival analysis by the nonparametric method of Kaplan Meier and the Cox regression model to determine risk ratios (FIR) of prognostic factors, Survival rates were 42% at 1 year, 21% at 2 years, and 8% at 5 years after diagnosis. Patients aged 50-64 were found to have poorer survival compared with those less than 50 (RR = 1.73, P = 0.03); the risk ratio for ages greater than or similar to = 65 was 1.88 (P = 0.03). Females had significantly better survival than males (RR = 0.71, P = 0.02). For each 100 rads dose of radiotherapy, the risk ratio was significantly decreased by 1% (RR = 0.99, P = 0.05); for each session of radiotherapy, the risk ratio was significantly decreased by 4% (RR = 0.96, P = 0.0001); for each square centimetre size of surface under radiotherapy, the risk ratio significantly increased (RR = 1,002, P = 0.04). We did not observe a significant difference on survival by histology, anatomical location of turnouts, or type of treatment (P > 0.05). Prognosis is extremely poor. 0 2001 Cancer Research Campaign.