Regulatory T cells in B cell follicles.
Regulatory T cells in B cell follicles.
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DOI：
10.4110/in.2014.14.5.227
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发表时间：
2014-10
期刊：
影响因子：
6
通讯作者：
Chung Y
中科院分区：
文献类型：
--
作者：
Chang JH;Chung Y
了解生发中心反应不仅对于设计针对感染原和恶性细胞的有效疫苗至关重要，而且对于开发治疗抗体介导的免疫疾病的治疗干预也至关重要。在这一领域的最新进展已经揭示了在卵泡中控制B细胞反应所必需的专门的T细胞亚群。这些细胞包括滤泡调节性T细胞和Qa-1限制性分化簇（CD）8+调节性T细胞。在这篇综述中，我们讨论了目前的知识有关的作用，调节性T细胞在B细胞滤泡。
Understanding germinal center reactions is crucial not only for the design of effective vaccines against infectious agents and malignant cells but also for the development of therapeutic intervention for the treatment of antibody-mediated immune disorders. Recent advances in this field have revealed specialized subsets of T cells necessary for the control of B cell responses in the follicle. These cells include follicular regulatory T cells and Qa-1-restricted cluster of differentiation (CD)8+ regulatory T cells. In this review, we discuss the current knowledge related to the role of regulatory T cells in the B cell follicle.