Imaging of dopamine transporters with technetium-99m TRODAT-1 and single photon emission computed tomography
Imaging of dopamine transporters with technetium-99m TRODAT-1 and single photon emission computed tomography
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DOI：
10.1111/jon2000104200
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发表时间：
2000-10-01
影响因子：
2.4
通讯作者：
Tang, J
中科院分区：
文献类型：
--
作者：
Bao, SY;Wu, JC;Tang, J
作者想评估Tc-99(m)-TRODAT-1作为测量帕金森病（PD）中多巴胺转运蛋白浓度变化的显像剂的有效性，并将这些发现与Hoehn和Yahr量表（HN）测量的疾病严重程度联系起来。对22名健康志愿者和27名HN I-IV期PD患者进行了评估。在注射Tc-99(m)-TRODAT-1 2小时后进行采集。在纹状体和小脑上绘制感兴趣的区域，并计算纹状体与小脑的比值（ST/CB）。PD患者纹状体Tc-99(m)-TRODAT-1摄取明显低于健康志愿者，且ST/CB比值与PD分期密切相关。本研究表明，使用Tc-99(m)-TRODAT-1和SPECT可以可视化和量化PD患者纹状体中多巴胺转运体的变化，并与HN分期和统一帕金森病评定量表（UPDRS）量表有良好的相关性。
The authors wanted to evaluate the usefulness of Tc-99(m)-TRODAT-1 as an imaging agent for measuring changes in dopamine transporter concentrations in Parkinson disease (PD) and correlate the findings to the severity of the disease as measured by the Hoehn and Yahr scale (HN). Twenty-two healthy volunteers and 27 patients with PD of HN stage I-IV were evaluated. Acquisitions were performed 2 hours after injection of Tc-99(m)-TRODAT-1. Regions of interest were drawn over the striatum and the cerebellum and the ratios of striatum-to-cerebellum (ST/CB) were calculated. Patients with PD showed a significant decrease in the striatal uptake of Tc-99(m)-TRODAT-1 compared to healthy volunteers, and the ST/CB ratios were closely related to the stage of PD. The present study demonstrates that it is possible to visualize and quantify changes in dopamine transporter in the striatum of patients with PD using Tc-99(m)-TRODAT-1 and SPECT with good correlation to HN stage and unified Parkinson's disease rating scale (UPDRS) scale.