The evolving role of dendritic spines and memory: Interaction(s) with estradiol.
The evolving role of dendritic spines and memory: Interaction(s) with estradiol.
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DOI：
10.1016/j.yhbeh.2015.05.004
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发表时间：
2015-08
影响因子：
3.5
通讯作者：
Luine V
中科院分区：
文献类型：
--
作者：
Frankfurt M;Luine V
据推测，记忆处理取决于突触可塑性，突触可塑性似乎在调节记忆的获取、巩固和保留方面发挥着作用。我们研究了雌性啮齿类动物一生中雌激素、识别记忆和海马体和内侧前额叶皮层（对记忆至关重要的区域）的树突棘密度之间的关系。本文回顾了有关树突棘可塑性在调节短期和长期记忆以及随衰老和阿尔茨海默病引起的记忆力下降方面的文献。它还讨论了急性和慢性雌激素治疗在这些过程中的作用。
Memory processing is presumed to depend on synaptic plasticity, which appears to have a role in mediating the acquisition, consolidation, and retention of memory. We have studied the relationship between estrogen, recognition memory, and dendritic spine density in the hippocampus and medial prefrontal cortex, areas critical for memory, across the lifespan in female rodents. The present paper reviews the literature on dendritic spine plasticity in mediating both short and long term memory, as well as the decreased memory that occurs with aging and Alzheimer's Disease. It also addresses the role of acute and chronic estrogen treatment in these processes.