Early Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein in Predicting the Outcome of Mild Traumatic Brain Injury
Early Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein in Predicting the Outcome of Mild Traumatic Brain Injury
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DOI：
10.1089/neu.2018.5952
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发表时间：
2019-05-15
影响因子：
4.2
通讯作者：
Posti, Jussi P.
中科院分区：
文献类型：
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作者：
Hossain, Iftakher;Mohammadian, Mehrbod;Posti, Jussi P.
本研究的目的是探讨轻度创伤性脑损伤（mTBI）患者早期胶质纤维酸性蛋白（GFAP）和神经丝轻蛋白（NF-L）水平与预后的相关性。共纳入107例mTBI患者（格拉斯哥昏迷量表>= 13），这些患者在到达24小时内可获得GFAP和NF-L血液样本。mTBI患者分为CT阳性组和CT阴性组。格拉斯哥结局量表扩展（GOSE）用于评估结果。结果被定义为完全（GOSE 8）和不完全（GOSE）
The purpose of this study was to correlate the early levels of glial fibrillary acidic protein (GFAP) and neurofilament light protein (NF-L) with outcome in patients with mild traumatic brain injury (mTBI). A total of 107 patients with mTBI (Glasgow Coma Scale >= 13) who had blood samples for GFAP and NF-L available within 24 h of arrival were included. Patients with mTBI were divided into computed tomography (CT)-positive and CT-negative groups. Glasgow Outcome Scale-Extended (GOSE) was used to assess the outcome. Outcomes were defined as complete (GOSE 8) versus incomplete (GOSE