Properties and structural basis of simple diffusion pathways in the erythrocyte membrane.
Properties and structural basis of simple diffusion pathways in the erythrocyte membrane.
复制标题
红细胞膜中简单扩散途径的特性和结构基础。
DOI：
10.1007/bfb0027721
复制
发表时间：
1977
期刊：
影响因子：
--
通讯作者：
B. Deuticke
中科院分区：
文献类型：
--
作者：
B. Deuticke
在膜现象的研究中，新概念和技术可能性的快速发展，受到来自许多学科的研究人员日益增长的兴趣的支持，在过去的几年中，提供了关于细胞膜的结构和功能的显著信息。感兴趣的是集中在膜的组成和组织的分析，或膜功能的描述。在后者中，负责膜作为物质的下坡和上坡运动的屏障或矢量催化剂的能力的传输特性是主要生理和生物医学相关性的主题。从历史上看，这种运输过程的表征主要涉及其动力学，并导致转移系统的数学描述，面向一般概念和已知的事实扩散和酶催化。在此基础上假设的途径是必要的模拟模型，其中，在原则上，相当数量的结构等价物可以分配。对于一个适当的任务，深入了解膜组织是必需的。只有同时考虑到动力学和结构特征，才有可能对分子通过其在膜中的路径的运动进行物理上正确的描述。目前最多只能为少数物体提供足够的信息来综合描述运输途径。对于真核细胞，特别是哺乳动物细胞膜，红细胞膜性质的结构和功能分析已经达到了一种状态，这可能证明主要从其结构基础来讨论转移过程的尝试是合理的。本审查报告就是在这一方面进行的。为了便于今后的工作，它还应服务于为”动力学家”提供可能与通路性质有关的红细胞膜成分的信息，并概述”结构-
The rapid development of new concepts and technical possibilities in the investigation of membrane phenomena, sustained by the growing interest of investigators from numerous disciplines, has provided in the past years a conspicuous body of information on the structure and function of cell membranes. Interest is focused either on the analysis of membrane composition and organization, or on the description of membrane functions. Among the latter, transport properties, responsible for the capability of membranes to serve as barriers or vectorial catalysts for downhill and uphill movements of matter, are a topic of major physiological and biomedical relevance. Historically, the characterization of such transport processes has primarily been concerned with their kinetics and led to mathematical descriptions of transfer systems, oriented at general concepts and known facts on diffusion and enzyme catalysis. The pathways postulated on this basis are of necessity analog models, to which, in principle, a considerable number of structural equivalents can be assigned. For a proper assignment, intimate knowledge about membrane organization is required. Only the consideration of both kinetic and structural features will render possible physically correct descriptions of the movement of molecules via their pathway in a membrane. Sufficient information for such an integrative description of transport pathways is presently at best available for a small number of objects. In case of eukaryotic, in particular mammalian cell membranes, the structural and functional analysis of erythrocyte membrane properties has reached a state, which may justify attempts to discuss transfer processes mainly in terms of their structural basis. The present review has been conceived under this aspect. To facilitate future work it shall furthermore serve the purpose to provide the" kineticist" with information on erythrocyte membrane constituents that may be relevant for the properties of pathways, and to outline to the" structural-