Apicoplast phylogeny reveals the position of Plasmodium vivax basal to the Asian primate malaria parasite clade
Apicoplast phylogeny reveals the position of Plasmodium vivax basal to the Asian primate malaria parasite clade
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DOI：
10.1038/s41598-019-43831-1
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发表时间：
2019-05-13
影响因子：
4.6
通讯作者：
Horii, Toshihiro
中科院分区：
文献类型：
--
作者：
Arisue, Nobuko;Hashimoto, Tetsuo;Horii, Toshihiro
间日疟原虫不仅感染人类，也感染非洲猿类。人类特有的间日疟原虫是从一个起源于非洲猿类寄生虫的单一祖先进化而来的。虽然先前的研究提出了将间日疟原虫（人类和非洲猿间日疟原虫的共同祖先）定位在亚洲灵长类寄生虫组合中的系统发育树，但其位置尚未得到有力的证实。我们确定了来自七种亚洲灵长类寄生虫的几乎完整的顶质体基因组序列，这些寄生虫是食蟹猴疟原虫（Plasmodium cynomolgi）（锡兰疟原虫（Plasmodium Ceylonensis）和Berok）、诺氏疟原虫（P. knowlesi）、脆性疟原虫（P. fragile）、菲尔德疟原虫（P. fieldi）、类卵疟原虫（P. simiovale）、猪疟原虫（P. hylobati）、伊氏疟原虫（P. inui）和感染非洲长尾猴的非洲灵长类寄生虫（P. gonderi）。疟原虫物种的系统发育关系进行了分析，使用新的和以前确定的顶质体基因组序列。对30个蛋白质编码基因的多基因最大似然分析没有将间日疟原虫定位在亚洲灵长类寄生虫Glade内，而是将其定位在Glade的基部，在非洲长尾猴寄生虫P. gonderi的分支之后。这一结果与间日疟原虫从遗传学上起源于非洲的新概念并不矛盾。这一结果也得到了使用7种灵长类疟原虫的大量核基因组数据进行的系统发育分析的支持。
The malaria parasite species, Plasmodium vivax infects not only humans, but also African apes. Human specific P. vivax has evolved from a single ancestor that originated from a parasite of African apes. Although previous studies have proposed phylogenetic trees positioning P. vivax (the common ancestor of human and African ape P. vivax) within the assemblages of Asian primate parasites, its position has not yet been robustly confirmed. We determined nearly complete apicoplast genome sequences from seven Asian primate parasites, Plasmodium cynomolgi (strains Ceylonensis and Berok), P. knowlesi P. fragile, P. fieldi, P. simiovale, P. hylobati, P. inui, and an African primate parasite, P. gonderi, that infects African guenon. Phylogenetic relationships of the Plasmodium species were analyzed using newly and previously determined apicoplast genome sequences. Multigene maximum likelihood analysis of 30 protein coding genes did not position P. vivax within the Asian primate parasite Glade but positioned it basal to the Glade, after the branching of an African guenon parasite, P. gonderi. The result does not contradict with the emerging notion that P. vivax phylogenetically originated from Africa. The result is also supported by phylogenetic analyses performed using massive nuclear genome data of seven primate Plasmodium species.