Neural systems responding to degrees of uncertainty in human decision-making
Neural systems responding to degrees of uncertainty in human decision-making
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DOI：
10.1126/science.1115327
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发表时间：
2005-12-09
期刊：
影响因子：
56.9
通讯作者：
Camerer, CF
中科院分区：
文献类型：
--
作者：
Hsu, M;Bhatt, M;Camerer, CF
关于人们如何在不同的概率（风险）水平下做出决策，我们已经知道得很多了。由于信息缺失（模糊性），当概率不确定时，人们对决策的神经基础知之甚少。在决策理论中，概率的模糊性不应影响选择。使用功能性脑成像，我们表明，在选择的模糊程度与杏仁核和眶额皮质的激活呈正相关，与纹状体系统呈负相关。此外，纹状体活动与预期奖励呈正相关。眶额部病变的神经科受试者对行为选择的模糊性和风险水平不敏感。这些数据表明，与决策理论相反，神经回路对不确定性的程度做出了反应。
Much is known about how people make decisions under varying levels of probability (risk). Less is known about the neural basis of decision-making when probabilities are uncertain because of missing information (ambiguity). In decision theory, ambiguity about probabilities should not affect choices. Using functional brain imaging, we show that the level of ambiguity in choices correlates positively with activation in the amygdala and orbitofrontal cortex, and negatively with a striatal system. Moreover, striatal activity correlates positively with expected reward. Neurological subjects with orbitofrontal lesions were insensitive to the level of ambiguity and risk in behavioral choices. These data suggest a general neural circuit responding to degrees of uncertainty, contrary to decision theory.