Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias.
Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias.
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DOI：
10.1007/s12311-015-0664-x
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Yuki N
中科院分区：
文献类型：
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作者：
Mitoma H;Adhikari K;Aeschlimann D;Chattopadhyay P;Hadjivassiliou M;Hampe CS;Honnorat J;Joubert B;Kakei S;Lee J;Manto M;Matsunaga A;Mizusawa H;Nanri K;Shanmugarajah P;Yoneda M;Yuki N
在过去的几年里，许多出版物表明，致残性小脑共济失调可能通过免疫介导的机制发展。在这篇共识论文中，我们讨论了主要描述的免疫介导的小脑共济失调的临床特征，并讨论了其假定的发病机制。免疫介导的小脑共济失调包括与抗GAD抗体相关的小脑共济失调、小脑型桥本脑病、原发性自身免疫性小脑共济失调、谷蛋白共济失调、米勒费舍尔综合征、与系统性红斑狼疮相关的共济失调和副肿瘤性小脑变性。免疫介导的小脑共济失调中，体液机制、细胞介导的免疫、炎症和血管损伤导致小脑缺陷。
In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto’s encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias.