Three-component reaction of aldose sugars, aryl amines, and 1,3-diones: a novel synthesis of annulated pyrroles.
Three-component reaction of aldose sugars, aryl amines, and 1,3-diones: a novel synthesis of annulated pyrroles.
复制标题
DOI：
10.1021/jo702012w
复制
发表时间：
2008-03
期刊：
影响因子：
--
通讯作者：
J. Yadav;B. Reddy;M. Srinivas;Ch. Divyavani;S. J. Basha;A. Sarma
中科院分区：
文献类型：
--
作者：
J. Yadav;B. Reddy;M. Srinivas;Ch. Divyavani;S. J. Basha;A. Sarma
醛糖与芳胺和1,3-二酮原位生成的胺胺在80℃的水中，在10 mol %的InCl3存在下顺利偶联，以相对较高的收率生成环状吡咯衍生物。使用InCl3，与水结合，使这个过程非常简单，更方便，更环保。
Aldose sugars undergo smooth coupling with enamines, generated in situ from aryl amines and 1,3-diketones, in the presence of 10 mol % of InCl3 in water at 80 degrees C to furnish annulated pyrrole derivatives in relatively good to high yields. The use of InCl3, in combination with water, makes this procedure quite simple, more convenient, and environmentally friendly.