NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice
NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice
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DOI：
10.1016/j.pbb.2007.07.018
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发表时间：
2007-12-01
影响因子：
3.6
通讯作者：
Nowak, Gabriel
中科院分区：
文献类型：
--
作者：
Poleszak, Ewa;Wlaz, Piotr;Nowak, Gabriel
在强迫游泳试验（FST）中，镁具有抗抑郁样活性。此外，镁和抗抑郁药联合使用也能增强这种活性。但是，这种活动所涉及的机制仍有待建立。在本研究中，我们研究了NMDA/谷氨酸通路在小鼠FST中镁活性的参与。在本实验中，我们研究了NMDA激动剂对镁诱导的FST活性的影响，以及NMDA拮抗剂对亚有效剂量镁的影响。镁诱导的抗抑郁样活性可被n -甲基- d -天冬氨酸（NMDA）拮抗。此外，低剂量、无效剂量的NMDA拮抗剂（CGP 37849、L-701,324、d -环丝氨酸和MK-801）与低剂量、无效剂量的镁一起施用，可显著减少FST的不动时间。FST剂量药物的活性并没有改变运动活动（MK-801引起的活动增加除外）。本研究提示NMDA/谷氨酸通路参与了小鼠FST中镁的抗抑郁样活性，进一步提示了镁的抗抑郁作用。(C) 2007爱思唯尔公司版权所有。
Antidepressant-like activity of magnesium in forced swim test (FST) was demonstrated previously. Also, enhancement of such activity by joint administration of magnesium and antidepressants was shown. However, the mechanism(s) involved in such activity remain to be established. In the present study we examined the involvement of NMDA/glutamate pathway in the magnesium activity in FST in mice.In the present study we investigated the effect of NMDA agonists on magnesium-induced activity in FST and the influence of NMDA antagonists with sub-effective doses of magnesium in this test. Magnesium-induced antidepressant-like activity was antagonized by N-methyl-D-aspartic acid (NMDA). Moreover, low, ineffective doses of NMDA antagonists (CGP 37849, L-701,324, D-cycloserine, and MK-801) administered together with low and ineffective doses of magnesium exhibit significant reduction of immobility time in FST. The active in FST doses of examined agents did not alter the locomotor activity (with an exception of increased activity induced by MK-801).The present study indicates the involvement of NMDA/glutamate pathway in the antidepressant-like activity of magnesium in mouse FST and further suggests antidepressant properties of magnesium. (C) 2007 Elsevier Inc. All rights reserved.