COVID-19: Structural Considerations for Virus Pathogenesis, Therapeutic Strategies and Vaccine Design in the Novel SARS-CoV-2 Variants Era.

COVID-19: Structural Considerations for Virus Pathogenesis, Therapeutic Strategies and Vaccine Design in the Novel SARS-CoV-2 Variants Era.
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DOI:
10.1007/s12033-021-00353-4
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发表时间:
2021-10
影响因子:
2.6
通讯作者:
Volkan E
Volkan E
中科院分区:
医学4区
文献类型:
--
作者:
Volkan E

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由SARS-CoV-2引起的COVID-19大流行在全球范围内影响了人类,造成了悲惨的后果;夺去了数百万人的生命,摧毁了经济,摧毁了公共卫生基础设施。在不到一年的时间里,使用各种巧妙方法的疫苗的出现被认为是隧道尽头的光明。然而,最近在世界多个地区出现的SARS-CoV-2变种揭示了抗击COVID-19的另一个障碍。这篇综述将强调SARS-CoV-2突变如何产生不同的病毒变体,可能会影响病毒的发病机制以及不同的治疗方法和疫苗设计。
COVID-19 pandemic caused by SARS-CoV-2 globally impacted the humanity causing tragic outcomes; costing millions of lives, destroying economies and demolishing public health infrastructures. The emergence of vaccines using various ingenious approaches in less than a year was deemed the light at the end of the tunnel. However, recent emergence of variants of SARS-CoV-2 in several parts of the world revealed that another hurdle is ahead in the fight against COVID-19. This review will highlight how SARS-CoV-2 mutations, creating different virus variants could potentially impact virus pathogenesis as well as different therapy approaches and vaccine design.
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