Interference control training for PTSD: A randomized controlled trial of a novel computer-based intervention
Interference control training for PTSD: A randomized controlled trial of a novel computer-based intervention
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DOI：
10.1016/j.janxdis.2015.05.010
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发表时间：
2015-08-01
影响因子：
10.3
通讯作者：
Lang, Ariel J.
中科院分区：
文献类型：
--
作者：
Bomyea, Jessica;Stein, Murray B.;Lang, Ariel J.
创伤后应激障碍(PTSD)是一种以持久的侵入性记忆为特征的慢性衰弱疾病。尽管创伤后应激障碍有有效的治疗方法，但有必要开发替代治疗方法。控制主动干预的能力减弱可能导致再次出现症状，并可能成为一种新的干预目标。本研究测试了一种旨在修改前瞻性干扰控制临床试验的干预措施。42名患有创伤后应激障碍的女性被随机分配到计算机化的认知训练或对照条件下。评估了这些计划对认知表现和症状的影响。与对照组相比，训练组的创伤后应激障碍再体验症状和干扰控制能力的改善明显更多。随着时间的推移，两组的其他创伤后应激障碍和一般痛苦症状都有同样的改善。这种类型的认知训练有望成为减轻创伤后应激障碍症状的一种新的干预措施，尽管其作用机制和对创伤后应激障碍模型的影响还需要进一步研究。(C)2015爱思唯尔有限公司。保留所有权利。
Post-traumatic stress disorder (PTSD) is a chronic and debilitating condition characterized by persistent intrusive memories. Although effective treatments exist for PTSD, there is a need for development of alternative treatments. Diminished ability to control proactive interference may contribute to re-experiencing symptoms and may be a novel intervention target. The present study tested an intervention designed to modify proactive interference control clinicaltrials.gov identifier: (NCT02139137). Forty-two women with PTSD were randomly assigned to a computerized cognitive training or a control condition. The impact of these programs on cognitive performance and symptoms was assessed. PTSD re-experiencing symptoms and interference control performance improved significantly more for individuals in the training group relative to those in the control group. Other PTSD and general distress symptoms improved equally over time in both groups. Cognitive training of this type may hold promise as a novel intervention for reducing PTSD symptoms, although the mechanism of action and implications for models of PTSD requires future study. (C) 2015 Elsevier Ltd. All rights reserved.