Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?
Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?
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DOI：
10.1155/2017/8619307
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发表时间：
2017
影响因子：
4.6
通讯作者：
Lyadova IV
中科院分区：
文献类型：
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作者：
Lyadova IV
杆菌感染结核病仍然是世界上最常见的传染病之一。感染的结果取决于宿主有效保护和平衡炎症反应的能力。中性粒细胞是参与这两个过程的先天免疫细胞。因此，在M.结核病感染，他们扮演双重角色。特别是，它们有助于产生效应T细胞，参与肉芽肿的形成，并直接参与组织坏死、破坏和感染传播。中性粒细胞具有很高的杀菌潜力。然而，关于它们消除M.结核病是有争议的，中性粒细胞耗竭实验的结果并不统一。因此，中性粒细胞在M.结核感染和决定这些作用的因素尚未完全了解。本文分析了结核病期间中性粒细胞防御和病理功能的数据，并考虑了解释结核病期间中性粒细胞双重性的假说。结核感染和结核病。
Infection with M. tuberculosis remains one of the most common infections in the world. The outcome of the infection depends on host ability to mount effective protection and balance inflammatory responses. Neutrophils are innate immune cells implicated in both processes. Accordingly, during M. tuberculosis infection, they play a dual role. Particularly, they contribute to the generation of effector T cells, participate in the formation of granuloma, and are directly involved in tissue necrosis, destruction, and infection dissemination. Neutrophils have a high bactericidal potential. However, data on their ability to eliminate M. tuberculosis are controversial, and the results of neutrophil depletion experiments are not uniform. Thus, the overall roles of neutrophils during M. tuberculosis infection and factors that determine these roles are not fully understood. This review analyzes data on neutrophil defensive and pathological functions during tuberculosis and considers hypotheses explaining the dualism of neutrophils during M. tuberculosis infection and tuberculosis disease.