Hematopoietic cell culture therapies (Part II): Clinical aspects and applications.
Hematopoietic cell culture therapies (Part II): Clinical aspects and applications.
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造血细胞培养疗法（第二部分）：临床方面和应用。
DOI：
10.1016/0167-7799(96)10054-8
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Papoutsakis,ET
中科院分区：
文献类型：
--
作者：
McAdams,TA;Winter,JN;Miller,WM;Papoutsakis,ET
本文分为两部分，第一部分介绍了造血细胞培养，并检查了影响培养性能的一些重要生长因子和理化参数。艾默生最近回顾了造血培养及其治疗应用的几个方面。在第二部分中，我们将介绍造血干细胞移植领域，并研究造血细胞体外扩增的可能应用。潜在的应用包括“移植物工程”（在移植后产生更快的短期移植物）、肿瘤清除、基因治疗、用于免疫治疗的树突状细胞的产生和用于输血的成熟血细胞的产生（图1）。
The first part’of this two-part review provided an introduction to hematopoietic cell culture, and exam-ined some of the important growth factors and physicochemical parameters that affect culture performance. Emerson has recently reviewed several aspects of hematopoietic culture and its therapeutic applications”. In this second part, we provide an introduction to the field of hematopoietic stem cell transplantation, and examine possible applications of ex vivo expansion of hematopoietic cells. Potential applications include ‘graft engineering’(to produce more rapid short-term engraftment after transplantation), tumor purging, gene therapy, generation of dendritic cells for immunotherapy and the production of mature blood cells for transfusion (Fig. 1).