Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines
Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines
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DOI：
10.1021/acscatal.8b02386
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发表时间：
2018-08
期刊：
影响因子：
12.9
通讯作者：
A. Toscani;C. Risi;G. Black;Nicola L. Brown;A. Shaaban;N. Turner;D. Castagnolo
中科院分区：
文献类型：
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作者：
A. Toscani;C. Risi;G. Black;Nicola L. Brown;A. Shaaban;N. Turner;D. Castagnolo
开发了一种由脂肪族四氢吡啶(THP)合成吡啶的可持续MAO-N生物催化工艺。利用MAO-N全细胞作为芳构化生物催化剂，在温和的反应条件下合成了高转化率的吡啶类化合物。最后通过原位19F核磁共振研究了全细胞生物催化转化的动力学过程。
A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.