Longitudinal Assessment of Concurrent Changes in Left Ventricular Ejection Fraction and Left Ventricular Myocardial Tissue Characteristics After Administration of Cardiotoxic Chemotherapies Using T1-Weighted and T2-Weighted Cardiovascular Magnetic Resonance
Longitudinal Assessment of Concurrent Changes in Left Ventricular Ejection Fraction and Left Ventricular Myocardial Tissue Characteristics After Administration of Cardiotoxic Chemotherapies Using T1-Weighted and T2-Weighted Cardiovascular Magnetic Resonance
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DOI：
10.1161/circimaging.114.002217
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发表时间：
2014-11-01
影响因子：
7.5
通讯作者：
Hundley, W. Gregory
中科院分区：
文献类型：
--
作者：
Jordan, Jennifer H.;D'Agostino, Ralph B., Jr.;Hundley, W. Gregory
背景：在蒽环类药物相关的小鼠心脏毒性模型中，心血管磁共振心肌对比增强t1加权信号强度的增加与心肌细胞损伤有关，并随左心室射血分数的降低而降低。我们试图确定T1和t2加权信号强度是否与接受潜在心脏毒性化疗的人类受试者左心室射血分数降低相关。方法和结果：在65例乳腺癌患者（n=51）或血液恶性肿瘤患者（n=14）中，我们使用盲法、非配对分析心血管磁共振图像，在开始潜在心脏毒性化疗前和3个月后测量左心室容积、射血分数和对比增强t1加权和t2加权信号强度。参与者年龄为51 +/- 12岁，其中55%接受蒽环类药物治疗，38%接受单克隆抗体治疗，6%接受抗微生物小管药物治疗。总体而言，左心室射血分数从57 +/- 6%降至54 +/- 7% (P
Background-In a murine anthracycline-related cardiotoxicity model, increases in cardiovascular magnetic resonance myocardial contrast-enhanced T1-weighted signal intensity are associated with myocellular injury and decreases with left ventricular ejection fraction. We sought to determine whether T1- and T2-weighted measures of signal intensity associate with decreases in left ventricular ejection fraction in human subjects receiving potentially cardiotoxic chemotherapy.Methods and Results-In 65 individuals with breast cancer (n=51) or a hematologic malignancy (n=14), we measured left ventricular volumes, ejection fraction, and contrast-enhanced T1-weighted and T2-weighted signal intensity before and 3 months after initiating potentially cardiotoxic chemotherapy using blinded, unpaired analysis of cardiovascular magnetic resonance images. Participants were aged 51 +/- 12 years, of whom 55% received an anthracycline, 38% received a monoclonal antibody, and 6% received an antimicrotubule agent. Overall, left ventricular ejection fraction decreased from 57 +/- 6% to 54 +/- 7% (P