Smart hydrogel based microsensing platform for continuous glucose monitoring.
Smart hydrogel based microsensing platform for continuous glucose monitoring.
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基于智能水凝胶的微传感平台，用于连续血糖监测。
DOI：
10.1109/iembs.2010.5626231
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Solzbacher,Florian
中科院分区：
文献类型：
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作者：
Tathireddy,Prashant;Avula,Mahender;Lin,Genyao;Cho,SeungHei;Guenther,Margarita;Schulz,Volker;Gerlach,Gerald;Magda,JulesJ;Solzbacher,Florian
在这篇论文中，我们介绍了限制在微压传感器中的葡萄糖敏感水凝胶对环境葡萄糖浓度变化的响应的初步结果。在pH为7.4的0.15M PBS溶液和pH为7.4时的小牛血清中，葡萄糖浓度在20~0 mM范围内递增变化，并记录传感器的响应。微型传感器在PBS和血清中的响应时间均为10分钟。本文报告了ETO灭菌传感器在小鼠皮下植入55天后的组织反应。对周围组织的初步分析显示，炎症被认为不会影响传感器的性能。
In this paper, we present preliminary results showing the response of glucose-sensitive hydrogels, confined in micro-pressure sensors, to the changes in environmental glucose concentration. The glucose concentrations were incrementally varied between 20 and 0mM in 0.15M PBS solution at 7.4 pH and bovine serum at 7.4 pH at room temperature and response of the sensor was recorded. The micro sensors demonstrate a response time of 10 minutes in both PBS and serum. Tissue response after 55 days of subcutaneous implantation of a EtO sterilized sensor in mice is presented. The preliminary analysis of the surrounding tissue shows inflammation which is believed not to interfere with the sensor performance.