CHOLESTEROL-LOWERING EFFECTS OF PSYLLIUM HYDROPHILIC MUCILLOID FOR HYPERCHOLESTEROLEMIC MEN
CHOLESTEROL-LOWERING EFFECTS OF PSYLLIUM HYDROPHILIC MUCILLOID FOR HYPERCHOLESTEROLEMIC MEN
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DOI：
10.1001/archinte.148.2.292
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发表时间：
1988-02-01
影响因子：
--
通讯作者：
BISHOP, CW
中科院分区：
文献类型：
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作者：
ANDERSON, JW;ZETTWOCH, N;BISHOP, CW
在一项双盲、安慰剂对照平行研究中，在26名轻度至中度高胆固醇血症（胆固醇水平范围为4.86至8.12 mmol/L [188至314 mg/dL]）男性患者中研究了车前子亲水性类黏蛋白对血清胆固醇水平的影响。在两周的基线期后，受试者在进餐时用3.4 g车前子或纤维素安慰剂治疗8周（每天三次剂量）。所有受试者维持其日常饮食，每天提供少于300 mg胆固醇，约20%的能量来自蛋白质，40%来自碳水化合物，40%来自脂肪。与基线值相比，用车前子治疗8周可使血清总胆固醇水平降低14.8%，低密度脂蛋白（LDL）胆固醇降低20.2%，LDL胆固醇与高密度脂蛋白胆固醇的比率降低14.8%。随着时间的推移，总胆固醇和低密度脂蛋白胆固醇的降低幅度逐渐增大，这种趋势似乎在第8周时仍在继续。车前子治疗不影响体重，血压，或高密度脂蛋白胆固醇，甘油三酯，葡萄糖，铁，或锌的血清水平。安慰剂治疗组未观察到血脂水平、体重、血压或其他血清参数的显著变化。受试者对欧车前治疗的依从性极佳，未观察到不良反应。这项研究的结果表明，车前子是一种有效的和耐受性良好的治疗轻度至中度高胆固醇血症。
The effect of psyllium hydrophilic mucilloid on serum cholesterol levels was investigated in 26 men with mild to moderate hypercholesterolemia (range of cholesterol level, 4.86 to 8.12 mmol/L [188 to 314 mg/dL]) in a double-blind, placebo-controlled parallel study. Following a two-week base-line period, subjects were treated for eight weeks with 3.4 g of psyllium or cellulose placebo at mealtimes (three doses per day). All subjects maintained their usual diets, which provided less than 300 mg of cholesterol per day and approximately 20% of energy from protein, 40% from carbohydrate, and 40% from fat. Eight weeks of treatment with psyllium reduced serum total cholesterol levels by 14.8%, low-density lipoprotein (LDL) cholesterol by 20.2%, and the ratio of LDL cholesterol to high-density lipoprotein cholesterol by 14.8% relative to baseline values. The reductions in total cholesterol and LDL cholesterol became progressively larger with time, and this trend appeared to be continuing at the eighth week. Psyllium treatment did not affect body weight, blood pressure, or serum levels of high-density lipoprotein cholesterol, triglycerides, glucose, iron, or zinc. No significant changes in serum lipid levels, body weight, blood pressure, or other serum parameters were observed with placebo treatment. Subject adherence to psyllium treatment was excellent, and no adverse effects were observed. Results of this study show that psyllium is an effective and well-tolerated therapy for mild to moderate hypercholesterolemia.