New pathways to control inflammatory responses in adipose tissue
New pathways to control inflammatory responses in adipose tissue
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DOI：
10.1016/j.coph.2013.04.008
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发表时间：
2013-08-01
影响因子：
4
通讯作者：
Fantuzzi, Giamila
中科院分区：
文献类型：
--
作者：
Akasheh, Rand T.;Pang, Jingbo;Fantuzzi, Giamila
肥胖的特征是脂肪组织中存在慢性炎症，特别是内脏间隙，这与肥胖相关合并症的发生有因果关系。这种联系可以是直接的，也可以是间接的，通过诱导胰岛素抵抗。本文综述了脂肪组织炎症的潜在药理靶点的最新证据，重点是正在研究的干预慢性炎症性疾病的介质，因此是可行的候选治疗药物。具体地说，我们讨论了炎症体及其下游产物作为抗炎策略的潜在靶点的证据，以及参与炎症消退阶段的T调节(Treg)细胞和介质，如解决素、保护素、膜联蛋白A1(ANXA1)和Galectins作为新型激动剂治疗的潜在靶点。
Obesity is characterized by the presence of chronic inflammation in adipose tissue, particularly in the visceral compartment, that has been causally linked to development of obesity-associated comorbidities. This link can be either direct or indirect, through induction of insulin resistance. This review summarizes recent evidence on potential pharmacological targets of adipose tissue inflammation, with emphasis on mediators that are being studied for intervention in chronic inflammatory diseases and are therefore viable therapeutical candidates. Specifically, we discuss evidence on the role of the inflammasome and its downstream products as a potential target for anti-inflammatory strategies as well as T regulatory (Treg) cells and mediators involved in the resolution phase of inflammation such as resolvins, protectins, annexin A1 (ANXA1) and galectins as potential targets for novel agonist therapies.