A phantom for diffusion-weighted MRI (DW-MRI)
A phantom for diffusion-weighted MRI (DW-MRI)
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DOI：
10.1002/jmri.23950
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发表时间：
2013-07-01
影响因子：
4.4
通讯作者：
Aboagye, Eric O.
中科院分区：
文献类型：
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作者：
Lavdas, Ioannis;Behan, Kevin C.;Aboagye, Eric O.
目的：开发组织等效扩散率材料并构建模拟生物组织中典型条件的球形扩散体模。此外，要评估的ADC测量的再现性从全身diffusion protocol.Materials和方法：镍掺杂的琼脂糖/蔗糖凝胶制造和用于建立一个球形的扩散体模与组织等效的放松和扩散室。凝胶的时间稳定性被监测了8周，并且使用相同的测量，在1.5特斯拉（T）临床系统中评估了ADC的再现性。结果：掺镍琼脂糖/蔗糖凝胶扩散特性的时间稳定性是极好的（ADC在所有体模隔室中的平均变异系数[CV]= 1.27%）。ADC测量的平均CV，不包括受人为因素影响的幻影车厢，为0.76%，表明使用EPI DW-MRI protocol的ADC测量的再现性是非常好的。结论：镍掺杂的琼脂糖/蔗糖凝胶可用作MRI扩散测量的参考材料，并显示出良好的短期稳定性相对于ADC。由这些材料制成的体模在优化DW-MRI协议、开发DW-MRI的新型脉冲序列或比较场强、供应商和成像中心之间的ADC值方面具有非常重要的价值。
Purpose: To develop tissue-equivalent diffusivity materials and build a spherical diffusion phantom which mimics the conditions typically found in biological tissues. Also, to assess the reproducibility of ADC measurements from a whole-body diffusion protocol.Materials and Methods: Nickel-doped agarose/sucrose gels were manufactured and used to build a spherical diffusion phantom with tissue-equivalent relaxation and diffusion compartments. The temporal stability of the gels was monitored for a period of 8 weeks and, using the same measurements, the reproducibility of ADC was assessed in a 1.5 Tesla (T) clinical system.Results: The temporal stability of the nickel-doped agarose/sucrose gels diffusion properties was excellent (average coefficient of variation [CV] for ADC in all phantom compartments = 1.27%). The average CV for ADC measurements, excluding the phantom compartments affected by artifacts, was 0.76% showing that the reproducibility of ADC measurements using an EPI DW-MRI protocol is very good.Conclusion: Nickel-doped agarose/sucrose gels can be used as reference materials for MRI diffusion measurements and show excellent short-term stability with respect to ADC. A phantom made of these materials can be invaluable in optimizing DW-MRI protocols, developing novel pulse sequences for DW-MRI, or comparing ADC values among field strengths, vendors, and imaging centers.