Preparation of layered calcium silicate organically modified with two types of functional groups for varying chemical stability
Preparation of layered calcium silicate organically modified with two types of functional groups for varying chemical stability
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DOI：
10.1080/21870764.2020.1854925
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发表时间：
2021-01-01
影响因子：
2.3
通讯作者：
Ohtsuki, Chikara
中科院分区：
文献类型：
--
作者：
Nakamura, Jin;Suzuki, Yuna;Ohtsuki, Chikara
本研究的重点是用两种有机官能团对层状硅酸钙进行有机改性，以控制化学稳定性。采用溶剂热法制备了不同氨丙基和苯基含量的有机改性层状硅酸钙。由有机硅烷衍生的多面体低聚倍半硅氧烷的副产物(R-n-SiO1.5(N))也在制备过程中形成，苯基三乙氧基硅烷的初始分数较高。用X射线衍射仪、核磁共振光谱、傅立叶变换红外光谱和拉曼光谱证实了两种有机基团修饰的层状硅酸钙的形成。样品中这些有机基团的含量反映了原料中硅烷的摩尔分数。在pH=7.4的缓冲溶液中浸泡24 h后，所有样品都很容易释放出钙和硅酸盐离子，但随着苯基的初始摩尔分数增加到75%，释放的硅酸盐和钙离子的量有减少的趋势。层状硅酸钙的化学稳定性随着其结构中引入的疏水官能团的增加而增加。这些结果表明，这些修饰在具有可调溶解度的生物材料中应用于骨重建是有潜力的。
This study focuses on organically modifying a layered calcium silicate with two types of organic functional groups to control chemical stability. Solvothermal processing was used to prepare organically modified layered calcium silicates with different contents of aminopropyl and phenyl groups. By-products of polyhedral oligomeric silsesquioxanes derived from organosilanes (R-n-SiO1.5(n)) were also formed in the sample powders upon preparation with a high initial fraction of phenyltriethoxysilane. The formation of layered calcium silicates modified with both organic groups was confirmed by X-ray diffractometry, nuclear magnetic resonance spectroscopy, Fourier-transform infrared spectroscopy, and Raman spectroscopy. The contents of these organic groups in the samples reflected the molar fractions of silanes in the starting materials. Although all samples readily released calcium and silicate ions into a buffer solution of pH = 7.4 after soaking for 24 h, the amounts of released silicate and calcium ions tended to decrease as the initial molar fraction of phenyl groups was increased up to 75 mol%. The chemical stability of the layered calcium silicates increased with the increase of the hydrophobic functional groups incorporated into their structure. These results indicate the potential for applying these modifications in biomaterials with tunable solubility for the purpose of bone reconstruction.