Feasibility of retinoids for the treatment of emphysema study
Feasibility of retinoids for the treatment of emphysema study
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DOI：
10.1378/chest.130.5.1334
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发表时间：
2006-11-01
期刊：
影响因子：
9.6
通讯作者：
Wise, Robert A.
中科院分区：
文献类型：
--
作者：
Roth, Michael D.;Connett, John E.;Wise, Robert A.
背景资料：在一些肺气肿动物模型中，类维生素A促进发育中的肺的肺泡分隔并刺激肺泡修复。方法：148名患有中度至重度COPD和肺气肿的主要成分的受试者，通过肺一氧化碳弥散量（DLCO）[预测值的37.1 +/- 12.0%]和CT密度掩膜（体素的38.5 +/-12.8
Background: Retinoids promote alveolar septation in the developing lung and stimulate alveolar repair in some animal models of emphysema.Methods: One hundred forty-eight subjects with moderate-to-severe COPD and a primary component of emphysema, defined by diffusing capacity of the lung for carbon monoxide (DLCO) [37.1 +/- 12.0% of predicted] and CT density mask (38.5 +/- 12.8% of voxels