Dramatic increase in cervical cancer registrations in young women in 2009 in England unlikely to be due to the new policy not to screen women aged 20-24
Dramatic increase in cervical cancer registrations in young women in 2009 in England unlikely to be due to the new policy not to screen women aged 20-24
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DOI：
10.1258/jms.2012.012081
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发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
Castanon, Alejandra
中科院分区：
文献类型：
--
作者：
Sasieni, Peter;Castanon, Alejandra
目的探讨2009年英格兰宫颈癌发病率增加17%是否与宫颈筛查政策的变化有关。方法分析英格兰、威尔士和苏格兰宫颈癌和宫颈上皮内瘤变3级（CIN3）的发病趋势。对 2007 年 4 月至 2011 年 8 月期间英国诊断的 4079 名 20-39 岁女性的浸润性宫颈癌数据进行了单岁分析。 结果 与 2008 年相比，2009 年英国 25-29 岁女性的宫颈癌发病率比 2008 年增加了 38%（95% 置信区间 [CI] 18-62%），增加了 30%。 35-39 岁女性增加 (11-51%)。 2010 年的比率与 2008 年相似。2000 年至 2010 年间，英格兰 25-29 岁女性的平均增长率并不高于苏格兰和威尔士（相对风险 0.98，95% CI 0.69-1.39）。在英格兰，自 2003 年以来，CIN3（尤其是 25-29 岁年龄段）逐渐增加，2009 年增加更为显着，但 2010 年有所下降。审计数据显示，2009/2010 年和 2010/2011 年，25 岁诊断出的癌症有所增加（P
Objective To explore whether the 17% increase in cervical cancer in England in 2009 was due to the change in cervical screening policy.Methods Trends in incidence of cervical cancer and of cervical intraepithelial neoplasia grade 3 (CIN3) were analysed for England, Wales and Scotland. Invasive cervical cancer data on 4079 cancers in women aged 20-39 diagnosed between April 2007 and August 2011 in England were analysed by single year of age.Results In England there was a 38% (95% confidence intervals [CI] 18-62%) increase in cervical cancer incidence rates in women aged 25-29 in 2009 relative to 2008, and a 30% (11-51%) increase in women aged 35-39. Compared rates in 2010 are similar to those in 2008. The average increase between 2000 and 2010 in women aged 25-29 was no greater in England than in Scotland and Wales (relative risk 0.98, 95% CI 0.69-1.39). In England there has been a gradual increase in CIN3 (particularly for ages 25-29) since 2003, with a more dramatic increase in 2009, but a fall in 2010. Audit data showed an increase in cancers diagnosed at age 25 in 2009/2010 and 2010/2011 (P