Inflammatory C-reactive protein and cytokine levels in asymptomatic people with chronic spinal cord injury
Inflammatory C-reactive protein and cytokine levels in asymptomatic people with chronic spinal cord injury
复制标题
DOI：
10.1016/j.apmr.2004.02.009
复制
发表时间：
2005-02-01
影响因子：
4.3
通讯作者：
Schreiber, P
中科院分区：
文献类型：
--
作者：
Frost, F;Roach, MJ;Schreiber, P
目的：确定血清学标志物信息与慢性脊髓损伤 (SCI) 患者临床特征之间的关系。设计：横断面研究。地点：学术医疗中心 SCI 门诊。参与者：37 名慢性 SCI 男性和 10 名健康对照受试者的方便样本。干预措施：不适用。主要结果指标：白细胞介素 6 (IL-6)、肿瘤的血清水平 坏死因子-α (TNF-α) 和 C 反应蛋白 (CRP)。 结果：以下结果在 P 小于 0.05 时达到统计学显着性。无症状慢性 SCI 患者与参考对照的血清 CRP 水平存在差异，但 IL-6 或 TNF-α 水平没有差异。在 SCI 患者中，较高水平的 CRP 与血红蛋白和白蛋白水平呈负相关。损伤后时间越长，TNF-α 值越低，而 TNF-α 水平越高，血清白蛋白越高。压疮和留置导尿管与较高的 CRP 平均水平相关，但与细胞因子 TNF-α 和 IL-6 无关。与其他膀胱管理方法相比，间歇性导尿与较低的 CRP 水平相关。结论：无症状的长期 SCI 患者，尤其是留置导尿管的患者，表现出全身炎症状态的血清学证据。没有证据表明促炎细胞因子升高。在留置导尿管和小皮肤溃疡的表面健康人群中检测到持续的全身炎症反应，进一步支持了对无导管排尿选择和压疮愈合的积极追求。
Objective: To determine the relation between serologic markers of information and clinical characteristics of people with chronic spinal cord injury (SCI).Design: Cross-sectional study.Setting: Academic medical center SCI outpatient clinic.Participants: Convenience sample of 37 men with chronic SCI and 10 healthy control subjects.Interventions: Not applicable.Main Outcome Measures: Serum levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP).Results: The following results achieved statistical significance at P less than .05. Asymptomatic chronic SCI patients differed from referent controls with respect to serum CRP levels but not IL-6 or TNF-alpha. In SCI patients, higher levels of CRP correlated negatively with hemoglobin and albumin levels. A longer time since injury correlated with lower TNF-alpha values, whereas higher TNF-a levels correlated with higher serum albumin. Pressure ulcers and indwelling urinary catheters were associated with higher mean levels of CRP but not of the cytokines TNF-alpha and IL-6. Intermittent urinary catheterization was associated with lower levels of CRP when compared with other methods of bladder management.Conclusions: Asymptomatic people with long-term SCI, especially those with indwelling urinary catheters, showed serologic evidence of a systemic inflammatory state. There was no evidence of an elevation in proinflammatory cytokines. Detection of an ongoing systemic inflammatory response in apparently healthy people with indwelling urinary catheters and small skin ulcers further supports the aggressive pursuit of catheter-free voiding options and pressure ulcer healing.