COVID-19 and diabetes mellitus: An unholy interaction of two pandemics
COVID-19 and diabetes mellitus: An unholy interaction of two pandemics
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DOI：
10.1016/j.dsx.2020.04.049
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发表时间：
2020-07-01
影响因子：
10
通讯作者：
Bhadada, Sanjay K.
中科院分区：
文献类型：
--
作者：
Pal, Rimesh;Bhadada, Sanjay K.
背景和目的：糖尿病与 COVID-19 患者的不良预后相关。另一方面，与应激性高血糖相比，COVID-19 会导致糖尿病患者的血糖异常恶化。在此，我们回顾了 COVID-19 和糖尿病之间的双向相互作用。方法：我们对 PubMed、EMBASE 和 Google Scholar 数据库中截至 2020 年 4 月 25 日的文章进行了广泛的文献检索，关键词如下：“COVID-19”、“SARS-CoV-2”、“糖尿病”、“糖尿病”、“SARS”、“感染”和“糖尿病管理”插入布尔运算符“AND”。结果：先天免疫受损、促炎细胞因子环境、ACE2 表达减少以及糖尿病患者使用肾素-血管紧张素-醛固酮系统拮抗剂会导致 COVID-19 预后不良。相反，直接β细胞损伤、细胞因子诱导的胰岛素抵抗、低钾血症和用于治疗COVID-19的药物（如皮质类固醇、洛匹那韦/利托那韦）可能会导致糖尿病患者的血糖控制恶化。结论：COVID-19和糖尿病之间的双向相互作用建立了一个恶性循环，其中COVID-19导致血糖异常和糖尿病恶化，反过来，加剧了 COVID-19 的严重性。因此，糖尿病患者必须采取一切必要的预防措施，在持续的大流行中确保良好的血糖控制。 (C) 2020 年由 Elsevier Ltd 代表印度糖尿病协会发布。
Background and aims: Diabetes mellitus is associated with poor prognosis in patients with COVID-19. On the other hand, COVID-19 contributes to worsening of dysglycemia in people with diabetes mellitus over and above that contributed by stress hyperglycemia. Herein, we have reviewed the two-way interactions between COVID-19 and diabetes mellitus.Methods: We have performed an extensive literature search for articles in PubMed, EMBASE and Google Scholar databases till April 25, 2020, with the following keywords: "COVID-19", "SARS-CoV-2", "diabetes", "diabetes mellitus", "SARS", "infection" and "management of diabetes mellitus" with interposition of the Boolean operator "AND".Results: Compromised innate immunity, pro-inflammatory cytokine milieu, reduced expression of ACE2 and use of renin-angiotensin-aldosterone system antagonists in people with diabetes mellitus contribute to poor prognosis in COVID-19. On the contrary, direct beta-cell damage, cytokine-induced insulin resistance, hypokalemia and drugs used in the treatment of COVID-19 (like corticosteroids, lopinavir/ritonavir) can contribute to worsening of glucose control in people with diabetes mellitus.Conclusions: The two-way interaction between COVID-19 and diabetes mellitus sets up a vicious cycle wherein COVID-19 leads to worsening of dysglycemia and diabetes mellitus, in turn, exacerbates the severity of COVID-19. Thus, it is imperative that people with diabetes mellitus take all necessary precautions and ensure good glycemic control amid the ongoing pandemic. (C) 2020 Published by Elsevier Ltd on behalf of Diabetes India.