Trends in Opioid Analgesic Abuse and Mortality in the United States
Trends in Opioid Analgesic Abuse and Mortality in the United States
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DOI：
10.1056/nejmsa1406143
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发表时间：
2015-01-15
影响因子：
158.5
通讯作者：
Green, Jody L.
中科院分区：
文献类型：
--
作者：
Dart, Richard C.;Surratt, Hilary L.;Green, Jody L.
在过去的二十年里，美国处方阿片类药物的使用大大增加; 2010年，有16，651例阿片类药物相关死亡。作为回应，已经实施了数百项联邦、州和地方干预措施。我们使用2013年的数据描述了处方阿片类镇痛药的转移和滥用趋势。方法我们使用了来自研究性滥用、转移和成瘾相关监测（RADARS）系统的五个项目来描述2002年至2013年期间六种处方阿片类镇痛药的所有产品和制剂的转移和滥用趋势：羟考酮、氢可酮、氢吗啡酮、芬太尼、吗啡和曲马多。该计划收集的数据从药物转移调查，中毒中心，药物滥用治疗中心，和大学students. ResultsPrescription阿片类镇痛药大幅增加，从2002年到2010年在美国，但从2011年到2013年略有下降。总的来说，RADARS系统项目报告说，从2002年到2010年，阿片类药物转移和滥用的比率大幅增加，但随后从2011年到2013年，这一比率趋于平稳或下降。与类阿片有关的死亡率以类似的模式上升和下降。报告的非医疗用途没有显着改变college students.ConclusionsPostmarketing监测表明，处方阿片类药物的转移和滥用增加2002年和2010年之间，2011年和2013年之间趋于稳定或下降。这些发现表明，美国可能在控制阿片类镇痛药滥用方面取得了进展。版权所有（C）2015马萨诸塞州医学会。
BackgroundThe use of prescription opioid medications has increased greatly in the United States during the past two decades; in 2010, there were 16,651 opioid-related deaths. In response, hundreds of federal, state, and local interventions have been implemented. We describe trends in the diversion and abuse of prescription opioid analgesics using data through 2013.MethodsWe used five programs from the Researched Abuse, Diversion, and Addiction-Related Surveillance (RADARS) System to describe trends between 2002 and 2013 in the diversion and abuse of all products and formulations of six prescription opioid analgesics: oxycodone, hydrocodone, hydromorphone, fentanyl, morphine, and tramadol. The programs gather data from drug-diversion investigators, poison centers, substance-abuse treatment centers, and college students.ResultsPrescriptions for opioid analgesics increased substantially from 2002 through 2010 in the United States but then decreased slightly from 2011 through 2013. In general, RADARS System programs reported large increases in the rates of opioid diversion and abuse from 2002 to 2010, but then the rates flattened or decreased from 2011 through 2013. The rate of opioid-related deaths rose and fell in a similar pattern. Reported nonmedical use did not change significantly among college students.ConclusionsPostmarketing surveillance indicates that the diversion and abuse of prescription opioid medications increased between 2002 and 2010 and plateaued or decreased between 2011 and 2013. These findings suggest that the United States may be making progress in controlling the abuse of opioid analgesics. Copyright (C) 2015 Massachusetts Medical Society.