Sound transmission along the ossicular chain in common wild-type laboratory mice
Sound transmission along the ossicular chain in common wild-type laboratory mice
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DOI：
10.1016/j.heares.2012.11.015
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发表时间：
2013-07-01
期刊：
影响因子：
2.8
通讯作者：
Olson, Elizabeth S.
中科院分区：
文献类型：
--
作者：
Dong, Wei;Varavva, Polina;Olson, Elizabeth S.
使用转基因老鼠可以加速听觉研究的进展。然而，小鼠听力的基本概况尚未被彻底记录。在当前的研究中，我们利用激光多普勒振动计测量了听骨链上几个关键点的声诱发振动，从而探索了小鼠中耳的传播。通过松弛部的开口进行观察。同时，使用微型压力传感器监测鼓膜上靠近鼓膜的压力。在听力研究中广泛使用的C57BL小鼠中进行了测量。我们的研究结果表明，听觉局部传递函数（定义为鼓膜处速度与压力之比）就像一个高通滤波器，在接近15 kHz的频率上几乎是平坦的，在较低的频率上迅速下降。小听骨沿线无相积。我们的结果表明，小鼠的小骨几乎像一个刚体一样运动。基于这些一维测量，incus-complex主要围绕解剖轴旋转，穿过前锤骨的卵圆末端和incus的短突，但也存在次要运动。本文是《MEMRO 2012》特刊的一部分。Elsevier B.V.出版
The use of genetically modified mice can accelerate progress in auditory research. However, the fundamental profile of mouse hearing has not been thoroughly documented. In the current study, we explored mouse middle ear transmission by measuring sound-evoked vibrations at several key points along the ossicular chain using a laser-Doppler vibrometer. Observations were made through an opening in pars flaccida. Simultaneously, the pressure at the tympanic membrane close to the umbo was monitored using a micro-pressure-sensor. Measurements were performed in C57BL mice, which are widely used in hearing research. Our results show that the ossicular local transfer function, defined as the ratio of velocity to the pressure at the tympanic membrane, was like a high-pass filter, almost flat at frequencies above similar to 15 kHz, decreasing rapidly at lower frequencies. There was little phase accumulation along the ossicles. Our results suggested that the mouse ossicles moved almost as a rigid body. Based on these 1-dimensional measurements, the malleus incus-complex primarily rotated around the anatomical axis passing through the gonial termination of the anterior malleus and the short process of the incus, but secondary motions were also present. This article is part of a Special Issue entitled "MEMRO 2012". Published by Elsevier B.V.