Cerebral pathways in processing of affective prosody: A dynamic causal modeling study
Cerebral pathways in processing of affective prosody: A dynamic causal modeling study
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DOI：
10.1016/j.neuroimage.2005.09.059
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发表时间：
2006-04-01
期刊：
影响因子：
5.7
通讯作者：
Wildgruber, D
中科院分区：
文献类型：
--
作者：
Ethofer, T;Anders, S;Wildgruber, D
本研究旨在探讨情绪性语音旋律（韵律）加工过程中神经结构的连接结构。24名受试者接受了事件相关功能磁共振成像（fMRI），同时对双耳呈现的形容词的韵律或语义的情感效价进行评级。传统的fMRI数据分析显示，激活右后颞中回和双侧额叶下部皮层在情感韵律的评价和左颞极，眶额，内侧上级额叶皮层在情感语义的判断。动态因果模型（DCM）与贝叶斯因子相结合，用于比较竞争的神经生理模型与不同的内在连接结构和输入区域的网络内的大脑区域的基础上的情感韵律的理解。组水平上的比较显示的模型，其中右颞叶皮层作为输入区域相比，其中一个额叶区被假定为接收外部输入的模型的优越性。此外，从右颞叶皮层平行信息传导的模型上级两个额叶完成串行处理步骤的模型。总之，连通性分析支持这样的观点，即情感韵律的评价需要事先分析的声学特征内的时间和信息的传输从颞叶皮层到额叶发生通过平行的途径。(c)2005年爱思唯尔公司All rights reserved.
This study was conducted to investigate the connectivity architecture of neural structures involved in processing of emotional speech melody (prosody). 24 subjects underwent event-related functional magnetic resonance imaging (fMRI) while rating the emotional valence of either prosody or semantics of binaurally presented adjectives. Conventional analysis of fMRI data revealed activation within the right posterior middle temporal gyrus and bilateral inferior frontal cortex during evaluation of affective prosody and left temporal pole, orbitofrontal, and medial superior frontal cortex during judgment of affective semantics. Dynamic causal modeling (DCM) in combination with Bayes factors was used to compare competing neurophysiological models with different intrinsic connectivity structures and input regions within the network of brain regions underlying comprehension of affecfive prosody. Comparison on group level revealed superiority of a model in which the right temporal cortex serves as input region as compared to models in which one of the frontal areas is assumed to receive external inputs. Moreover, models with parallel information conductance from the right temporal cortex were superior to models in which the two frontal lobes accomplish serial processing steps. In conclusion, connectivity analysis supports the view that evaluation of affective prosody requires prior analysis of acoustic features within the temporal and that transfer of information from the temporal cortex to the frontal lobes occurs via parallel pathways. (c) 2005 Elsevier Inc. All rights reserved.