Wet-laboratory Experiments and Computer Simulation of Growing Cell Clusters
Wet-laboratory Experiments and Computer Simulation of Growing Cell Clusters
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DOI：
10.1109/globecom48099.2022.10000716
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发表时间：
2022-12
期刊：
影响因子：
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通讯作者：
Karin Matsushita;T. Nakano
中科院分区：
文献类型：
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作者：
Karin Matsushita;T. Nakano
本文通过实验证明，空间分布的细胞团簇可以生长分支，形成分子通信网络。本文还开发了细胞的计算模型，以了解细胞簇生长的生物物理机制。在这个模型中，细胞利用吸引力和排斥力形成一个簇。然后，细胞根据与它们物理接触的细胞的数量，改变它们的状态，成为领导者或追随者。那些成为领导者的细胞使用前进力量并离开集群，而那些成为追随者的细胞使用跟随力量跟随他们的领导者。通过领导者和追随者之间的相互作用，集群创造并发展其分支。我们使用计算模型进行计算机模拟，并了解模型参数如何影响集群创建和增长的分支的数量和长度。本文中描述的计算模型和模拟结果将有助于理解空间分布的细胞簇如何生长并最终形成合成的分子通信网络。
This paper demonstrates experimentally that spatially distributed cell clusters grow their branches and form a molecular communication network. This paper also develops a computational model of cells to understand the biophysical mechanisms by which cell clusters grow. In the model, cells form a cluster using attractive and repulsive forces. Cells then change their state to be leaders or followers, depending on the number of cells with which the cells are in physical contact. Those cells that become leaders use forward forces and move away from the cluster while those that become followers use following forces to follow their leaders. Through the interplay between leaders and followers, the cluster creates and grows its branches. We conduct computer simulations using the computational model and understand how the model parameters affect the number and length of branches that the cluster creates and grows. The computational model and simulation results described in this paper will help understand how spatially distributed cell clusters grow and eventually form a synthetic molecular communication network.