Autonomic imbalance induced breakdown of long-range dependence in healthy heart rate
Autonomic imbalance induced breakdown of long-range dependence in healthy heart rate
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DOI：
10.1055/s-0038-1625402
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发表时间：
2007-01-01
影响因子：
1.7
通讯作者：
Yamamoto, Y.
中科院分区：
文献类型：
--
作者：
Aoyagi, N.;Struzik, Z. R.;Yamamoto, Y.
目的：心率的长程相关性与自主神经平衡关系的研究方法：采用去趋势波动分析（DFA）研究心率变异性的分形标度特性。11名健康受试者连续两天接受检查，包括日常活动、长时间剧烈实验运动和睡眠。我们还考虑了两个患者组的自主神经功能障碍的特点是选择性交感神经和副交感神经domination.Results：鲁棒的长期依赖性的心率观察到只有在日常活动的状态，其特征在于平衡的自主交感神经和副交感神经调节的典型的正常心率。这证实了先前假设的心率调节的行为独立性，但揭示了1/f，长程依赖性的发生仅限于自主平衡的状态。交感神经主导的高心率状态（在剧烈的实验性运动中实现）和副交感神经主导的低心率状态（在（深）睡眠中普遍存在）的特征都是不相关的、接近白噪声样的标度（scaling），缺乏长程依赖性。值得注意的是，长期以来，在交感神经和副交感神经支配状态下的健康心率中观察到的范围相关性与先前已经被证实的增加的相关性形成鲜明对比。分别在患有原发性自主神经衰竭和充血性心力衰竭的患者中观察到神经源性副交感神经和交感神经优势。我们的研究结果进一步揭示了心率动力学的诊断能力，通过区分生理健康状态的病理。
Objectives: The investigation of the relation between the long-range correlation property of heart rate and autonomic balance:Methods: An investigation of the fractal scaling properties of heart rate variability was carried out by using detrended fluctuation analysis (DFA). Eleven healthy subjects were examined for two consecutive days, which included usual daily activity, strenuous prolonged experimental exercise, and sleep. We also considered two patient groups with autonomic dysfunction characterized by selective sympathetic and parasympathetic dominance.Results: Robust long-range dependence in heart rate is observed only in the state of usual daily activity, characterized by normal heart rate typical of balanced autonomic sympathetic and parasympathetic regulation. This confirms the previously postulated behavioral independence of heart rate regulation, but reveals that the occurrence of 1/f, long-range dependence is restricted to only the state of autonomic balance. Both the sympathetic dominant high heart rate state, realized during strenuous experimental exercise, and the parasympathetic dominant low heart rate state, prevalent in (deep) sleep, are characterized by uncorrelated, near white-noise-like scaling, lacking long-range dependence.Conclusion: Remarkably, the breakdown of the long-range correlations observed in healthy heart rate in the states of sympathetic and parasympathetic dominance is in stark contrast to the increased correlations which have previously been observed in neurogenic parasympathetic and sympathetic dominance in patients suffering from primary autonomic failure and congestive heart failure, respectively. Our findings further reveal the diagnostic capabilities of heart rate dynamics, by differentiating physiological healthy states from pathology.