Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma.
Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma.
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DOI：
10.2174/1570159x14666160223121002
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发表时间：
2017
影响因子：
5.3
通讯作者：
Broome AM
中科院分区：
文献类型：
--
作者：
Bredlau AL;Dixit S;Chen C;Broome AM
弥漫性内在脑桥胶质瘤（DIPG）是一种常见于小学儿童脑桥的致命性肿瘤。这些肿瘤是II-IV级胶质瘤，当用标准护理（SOC）疗法治疗时，从诊断起的中位生存期小于1年。纳米技术可以为DIPG的治疗提供治疗选择。目前正在研究多种纳米颗粒制剂用于治疗DIPG。基于稳定元素的纳米颗粒、聚合物纳米颗粒和有机纳米颗粒正在开发用于治疗脑肿瘤，包括DIPG。随着解决穿越血脑屏障（BBB）困难的递送技术的开发，纳米颗粒的靶向现在是可能的。治疗诊断纳米颗粒，治疗和诊断纳米颗粒的组合，改善癌组织的成像，同时将治疗递送到局部区域。然而，应将额外的时间和注意力用于开发用于治疗一致致命的儿科疾病DIPG的纳米颗粒递送系统。
Diffuse intrinsic pontine gliomas (DIPGs) are invariably fatal tumors found in the pons of elementary school aged children. These tumors are grade II-IV gliomas, with a median survival of less than 1 year from diagnosis when treated with standard of care (SOC) therapy. Nanotechnology may offer therapeutic options for the treatment of DIPGs. Multiple nanoparticle formulations are currently being investigated for the treatment of DIPGs. Nanoparticles based upon stable elements, polymer nanoparticles, and organic nanoparticles are under development for the treatment of brain tumors, including DIPGs. Targeting of nanoparticles is now possible as delivery techniques that address the difficulty in crossing the blood brain barrier (BBB) are developed. Theranostic nanoparticles, a combination of therapeutics and diagnostic nanoparticles, improve imaging of the cancerous tissue while delivering therapy to the local region. However, additional time and attention should be directed to developing a nanoparticle delivery system for treatment of the uniformly fatal pediatric disease of DIPG.