Evidence for the glycation hypothesis of aging from the food-restricted rodent model.
Evidence for the glycation hypothesis of aging from the food-restricted rodent model.
复制标题
来自食物限制的啮齿动物模型的衰老糖化假说的证据。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
C. Mcmahan
中科院分区：
文献类型：
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作者：
E. Masoro;Michael S. Katz;C. Mcmahan
Glucose has been proposed as a mediator of aging processes by means of glycation reactions resulting in advanced glycosylation end-products, thereby altering protein and DNA function. Testing this provocative concept has a high priority in gerontologic research. In this study, food restriction of rats--a procedure which markedly retards aging processes--was used to test the glycation hypothesis. Food-restricted rats were found to have a sustained plasma glucose concentration and percentage glycosylation of hemoglobin significantly lower than those of ad libitum fed rats. These findings are consistent with and provide support for the glycation hypothesis.
