Photocrosslinkable and elastomeric hydrogels for bone regeneration: PHOTOCROSSLINKABLE AND ELASTOMERIC HYDROGELS
Photocrosslinkable and elastomeric hydrogels for bone regeneration: PHOTOCROSSLINKABLE AND ELASTOMERIC HYDROGELS
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用于骨再生的光交联和弹性水凝胶：光交联和弹性水凝胶
DOI：
10.1002/jbm.a.35621
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发表时间：
2016
影响因子：
4.9
通讯作者：
Gaharwar, Akhilesh K.
中科院分区：
文献类型：
--
作者：
Thakur, Teena;Xavier, Janet R.;Cross, Lauren;Jaiswal, Manish K.;Mondragon, Eli;Kaunas, Roland;Gaharwar, Akhilesh K.
纳米复合生物材料由于其独特的物理、化学和生物学特性，在细胞和组织工程中得到了广泛的研究。在这里，我们研究了从纳米羟基磷灰石（nHAp）和明胶甲基丙烯酰（GelMA）的光交联和弹性纳米复合水凝胶的机械，流变学和降解性能。添加nHAp导致机械刚度和生理稳定性显著增加。细胞容易在纳米复合材料表面上粘附和增殖。弹性体纳米复合材料上的细胞的周期性拉伸显示，nHAp引起了更强的取向响应的应变方向。在体外研究突出增强的生物活性的纳米复合材料，由碱性磷酸酶（ALP）的活动。总的来说，弹性体和可光交联的纳米复合材料水凝胶可用于骨再生的微创治疗。© 2016 Wiley Periodicals，Inc. J Biomed Mater Res Part A：104A：879-888，2016.
Nanocomposite biomaterials are extensively investigated for cell and tissue engineering applications due their unique physical, chemical and biological characteristics. Here, we investigated the mechanical, rheological, and degradation properties of photocrosslinkable and elastomeric nanocomposite hydrogels from nanohydroxyapatite (nHAp) and gelatin methacryloyl (GelMA). The addition of nHAp resulted in a significant increase in mechanical stiffness and physiological stability. Cells readily adhere and proliferate on the nanocomposite surfaces. Cyclic stretching of cells on the elastomeric nanocomposites revealed that nHAp elicited a stronger alignment response in the direction of strain.In vitrostudies highlight enhanced bioactivity of nanocomposites as determined by alkaline phosphate (ALP) activity. Overall, the elastomeric and photocrosslinkable nanocomposite hydrogels can be used for minimally invasive therapy for bone regeneration. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 879–888, 2016.