Developmental differences in neuronal engagement during implicit encoding of emotional faces: an event-related fMRI study
Developmental differences in neuronal engagement during implicit encoding of emotional faces: an event-related fMRI study
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DOI：
10.1111/1469-7610.00186
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发表时间：
2003-10-01
影响因子：
7.6
通讯作者：
Ernst, M
中科院分区：
文献类型：
--
作者：
Nelson, EE;McClure, EB;Ernst, M
背景：先前的研究证明情绪和记忆过程之间存在强烈的相互作用。这些相互作用已被证明在发育和精神病理中有所不同，特别是情绪和焦虑障碍。方法：本研究使用功能神经成像来评估青少年和成人在情感刺激的内隐编码过程中神经元参与模式的差异程度。研究对象在观看带有愤怒、恐惧、快乐和中性表情的面孔时，进行了快速事件相关功能磁共振成像。进行扫描后记忆测试。结果：与先前的研究结果一致，青少年和成年人在观看随后识别的刺激时都表现出左腹外侧前额叶皮层的参与。与随后识别特定面部情绪类型相关的神经元激活模式出现了年龄差异。与成年人相比，青少年在观看随后记忆的愤怒面孔时，前扣带表现出更多的活动，而在观看随后记忆的恐惧面孔时，右颞极表现出更多的活动。相反，成年人在观看随后记忆的快乐面孔时，亚属前扣带表现出更多的活动，而在观看随后记忆的中性面孔时，右后海马体表现出更多的活动。这些年龄相关的差异是在行为表现没有差异的情况下出现的。结论：这些发现记录了情感回路参与记忆形成程度的发育差异。
Background: Prior studies document strong interactions between emotional and mnemonic processes. These interactions have been shown to vary across development and psychopathology, particularly mood and anxiety disorders. Methods: The present study used functional neuroimaging to assess the degree to which adolescents and adults differ in patterns of neuronal engagement during implicit encoding of affective stimuli. Subjects underwent rapid event-related fMRI while viewing faces with angry, fearful, happy, and neutral expressions. A surprise post-scan memory test was administered. Results: Consistent with previous findings, both adolescents and adults displayed engagement of left ventrolateral prefrontal cortex when viewing subsequently recognized stimuli. Age differences emerged in patterns of neuronal activation associated with subsequent recognition of specific face-emotion types. Relative to adults, adolescents displayed more activity in the anterior cingulate when viewing subsequently remembered angry faces, and more activity in the right temporal pole when viewing subsequently remembered fear faces. Conversely, adults displayed more activity in the sub-genual anterior cingulate when viewing subsequently remembered happy faces and more activity in the right posterior hippocampus when viewing subsequently remembered neutral faces. These age-related differences emerged in the absence of differences in behavioral performance. Conclusions: These findings document developmental differences in the degree to which engagement of affective circuitry contributes to memory formation.