Effect of Vitamin D and/or Marine n-3 Fatty Acid Supplementation on Changes in Migraine Frequency and Severity.
Effect of Vitamin D and/or Marine n-3 Fatty Acid Supplementation on Changes in Migraine Frequency and Severity.
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DOI：
10.1016/j.amjmed.2020.11.023
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Kurth T
中科院分区：
文献类型：
--
作者：
Rist PM;Buring JE;Cook NR;Manson JE;Kurth T
补充剂，包括维生素D和海洋ω-3（n-3）脂肪酸，是否可以有效地预防偏头痛，这是很有兴趣的。然而，很少有研究评估维生素D或n-3脂肪酸补充剂是否可以降低偏头痛的频率或严重程度。维生素D和OmegA-3 TriaL（VITAL）的参与者被分配到维生素D3（2000 IU/d）或海洋n-3脂肪酸（1 g/d）补充剂中。偏头痛的终生病史在试验开始后的中位数为4.6年进行评估。个人被要求自我报告过去5年中偏头痛频率（无变化，更频繁或更少）和严重程度（无变化，更严重，不太严重）的变化。我们使用卡方检验比较了活性剂组和安慰剂组报告偏头痛频率和严重程度变化的个体比例。在VITAL的25，871名参与者中，1032名参与者可能有偏头痛病史，并提供了偏头痛频率和严重程度变化的信息。报告偏头痛频率降低的个体百分比在活性维生素D（69.0%）和安慰剂维生素D（68.4%）（p值=0.54）或活性n-3脂肪酸（67.8%）和安慰剂n-3脂肪酸（69.6%）（p值=0.82）之间没有差异。同样，报告偏头痛严重程度降低的个体百分比在活性维生素D（64.1%）和安慰剂维生素D（65.0%）（p值=0.86）之间或活性维生素D（64.5%）和安慰剂n-3脂肪酸（64.5%）（p值=0.96）之间没有差异。与安慰剂相比，维生素D和海洋n-3脂肪酸补充剂都不会影响中年或老年人的偏头痛频率或严重程度。
There is interest in whether supplements, including vitamin D and marine omega-3 (n-3) fatty acids, may be effective migraine prophylaxis. However, few studies have evaluated whether vitamin D or n-3 fatty acid supplementation may reduce migraine frequency or severity. Participants in the VITamin D and OmegA-3 TriaL (VITAL) were assigned to vitamin D3 (2000 IU/d) or marine n-3 fatty acid (1 g/d) supplementation in a two-by-two factorial design. Lifetime history of migraine was assessed a median of 4.6 years after the start of the trial. Individuals were asked to self-report changes in migraine frequency (no change, more frequent, or less frequent) and severity (no change, more severe, less severe) in the past 5 years. We used chi-square tests to compare proportions of individuals reporting changes in migraine frequency and severity between active and placebo groups. Among the 25,871 participants in VITAL, 1032 participants had a history of probable migraine and provided information on changes in migraine frequency and severity. The percentage of individuals reporting decreases in migraine frequency did not differ between active (69.0%) and placebo vitamin D (68.4%) (p-value=0.54) or between active (67.8%) and placebo n-3 fatty acid (69.6%) (p-value=0.82). Similarly, the percentage of individuals reporting decreases in migraine severity did not differ between active (64.1%) and placebo vitamin D (65.0%) (p-value=0.86) or between active (64.5%) and placebo n-3 fatty acid (64.5%) (p-value=0.96). Neither vitamin D nor marine n-3 fatty acid supplementation, compared to placebo, affected migraine frequency or severity among middle-aged or older adults.
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DOI：
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发表时间：
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期刊：
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影响因子：
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