Cardiac fibroblast: the renaissance cell.
Cardiac fibroblast: the renaissance cell.
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DOI：
10.1161/circresaha.109.209809
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发表时间：
2009-12-04
影响因子：
20.1
通讯作者：
Baudino TA
中科院分区：
文献类型：
--
作者：
Souders CA;Bowers SL;Baudino TA
心脏的永久性细胞成分包括心脏成纤维细胞、肌细胞、内皮细胞和血管平滑肌细胞。先前的研究表明，心脏细胞群在胚胎发育、新生儿发育和成年期间存在波动变化。瞬时细胞群包括淋巴细胞、肥大细胞和巨噬细胞，它们可以与这些永久性细胞相互作用，影响心脏功能。还观察到，不同物种的心脏细胞群的组成有显著差异，这在检查心肌重塑时可能很重要。目前的理论认为，成纤维细胞构成了心脏最大的细胞群；然而，这似乎因物种而异，尤其是老鼠。心肌成纤维细胞在维持正常心功能以及心肌梗死和高血压等病理状态下的心脏重塑中发挥着关键作用。这些细胞具有多种功能，包括细胞外基质的合成和沉积，与肌细胞的细胞间通讯，与其他成纤维细胞以及内皮细胞的细胞间信号传导。这些接触影响电生理特性，生长因子和细胞因子的分泌，以及增强血管形成。虽然对这些过程有大量的了解，但对成纤维细胞及其在发育或心脏重塑过程中血管生成中的作用知之甚少。在这篇综述中，我们提供了对心脏成纤维细胞的各种特性的见解，这些特性有助于说明它们在维持正常心脏功能中的重要性，以及它们在心脏重塑中的关键作用。
The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes, endothelial cells and vascular smooth muscle cells. Previous studies have demonstrated that there are undulating changes in cardiac cell populations during embryonic development, through neonatal development and into the adult. Transient cell populations include lymphocytes, mast cells and macrophages, which can interact with these permanent cell types to affect cardiac function. It has also been observed that there are marked differences in the makeup of the cardiac cell populations depending on the species, which may be important when examining myocardial remodeling. Current dogma states that the fibroblast makes up the largest cell population of the heart; however, this appears to vary for different species, especially mice. Cardiac fibroblasts play a critical role in maintaining normal cardiac function, as well as in cardiac remodeling during pathological conditions such as myocardial infarct and hypertension. These cells have numerous functions, including synthesis and deposition of extracellular matrix, cell-cell communication with myocytes, cell-cell signaling with other fibroblasts, as well as with endothelial cells. These contacts affect the electrophysiological properties, secretion of growth factors and cytokines, as well as potentiating blood vessel formation. While a plethora of information is known about several of these processes, relatively little is understood about fibroblasts and their role in angiogenesis during development or cardiac remodeling. In this review we provide insight into the various properties of cardiac fibroblasts that helps illustrate their importance in maintaining proper cardiac function, as well as their critical role in the remodeling heart.