Neuromuscular recovery using calcium protease inhibition after median nerve repair in primates.
Neuromuscular recovery using calcium protease inhibition after median nerve repair in primates.
复制标题
灵长类动物正中神经修复后使用钙蛋白酶抑制进行神经肌肉恢复。
DOI：
10.1073/pnas.86.15.5983
复制
发表时间：
1989
影响因子：
11.1
通讯作者：
Stracher,A
中科院分区：
文献类型：
--
作者：
Badalamente,MA;Hurst,LC;Stracher,A
研究了三肽亮抑肽对猴正中神经切断和神经外膜修复后肌肉和神经中钙激活中性蛋白酶的抑制作用。结果表明，神经修复后的蛋白酶的抑制有利于形态恢复在失神经的鱼际肌肉和远端鱼际神经分支。此外，通过感觉和运动传导速度测量，在神经修复后，亮抑酶肽治疗的动物中促进了功能恢复。毒理学试验表明，亮抑酶肽以18 mg/kg肌内给药，每日两次，持续6个月，对血液学、凝血或血浆补体成分C3谱无不良影响。这些数据表明亮抑酶肽是一种有效和安全的辅助周围神经修复。
Inhibition of calcium-activated neutral protease, in muscle and nerve, by the tripeptide leupeptin after median nerve transection and epineural repair in monkeys (Cebus apella) was studied. Results indicate that inhibition of the protease after nerve repair facilitates morphologic recovery in denervated thenar muscles and in distal thenar nerve branches. In addition, functional recovery was facilitated in leupeptin-treated animals after nerve repair as measured by sensory and motor conduction velocities. Toxicologic testing showed that leupeptin, administered at 18 mg/kg, intramuscularly, twice daily, for 6 months did not adversely affect hematology, clotting, or plasma complement component C3 profiles. These data indicate that leupeptin is an effective and safe adjunct to peripheral nerve repair.