Obesity, Lifestyle Factors, and Risk of Myelodysplastic Syndromes in a Large US Cohort
Obesity, Lifestyle Factors, and Risk of Myelodysplastic Syndromes in a Large US Cohort
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DOI：
10.1093/aje/kwp074
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发表时间：
2009-06-15
影响因子：
5
通讯作者：
Schatzkin, Arthur
中科院分区：
文献类型：
--
作者：
Ma, Xiaomei;Lim, Unhee;Schatzkin, Arthur
骨髓增生异常综合征（MDS）的病因尚未完全了解。作者研究了肥胖和生活方式因素与MDS的关系，研究对象为471，799名年龄在50-71岁之间的人，这些人于1995-1996年被纳入美国国立卫生研究院-美国退休人员协会饮食与健康研究，这是一项大型的美国前瞻性研究。在2001-2003年期间，193人被诊断为MDS。观察到基线时的体重指数（BMI;体重（kg）/身高（m）（2））与MDS之间存在显著正相关。与BMI小于25.0的人相比，BMI为25.0- = 30.0的人的风险比< 30.0 and >分别为1.15（95%置信区间（CI）：0.81，1.64）和2.18（95% CI：1.51，3.17;趋势P < 0.001）。这种关联不受体力活动、吸烟或饮酒的影响。如既往研究所报告，与从不吸烟者相比，既往吸烟者（风险比= 1.68，95% CI：1.17，2.41）和当前吸烟者（风险比= 3.17，95% CI：2.02，4.98）的MDS风险升高。在这项分析中，体力活动、饮酒、肉类摄入、水果和蔬菜摄入似乎对MDS的风险没有显著影响。这项MDS的前瞻性研究表明肥胖和吸烟都是可改变的危险因素。
The etiology of myelodysplastic syndromes (MDS) is not well understood. The authors examined the relations of obesity and lifestyle factors to MDS in a cohort of 471,799 persons aged 50-71 years who were recruited into the National Institutes of Health-AARP Diet and Health Study, a large US prospective study, in 1995-1996. Incident MDS was diagnosed in 193 persons during 2001-2003. A significant positive association was observed between body mass index (BMI; weight (kg)/height (m)(2)) at baseline and MDS. Compared with persons with a BMI less than 25.0, the hazard ratios for persons with BMIs of 25.0-< 30.0 and >= 30.0 were 1.15 (95% confidence interval (CI): 0.81, 1.64) and 2.18 (95% CI: 1.51, 3.17; P for trend < 0.001), respectively. The association was not affected by physical activity, cigarette smoking, or alcohol intake. As reported in previous studies, the risk of MDS was elevated among former smokers (hazard ratio = 1.68, 95% CI: 1.17, 2.41) and current smokers (hazard ratio = 3.17, 95% CI: 2.02, 4.98) as compared with never smokers. Physical activity, alcohol consumption, meat intake, and fruit and vegetable intake did not appear to significantly influence the risk of MDS in this analysis. This prospective investigation of MDS implicates both obesity and smoking as modifiable risk factors.