Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi
Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi
复制标题
DOI：
10.1016/j.mycres.2007.08.017
复制
发表时间：
2008-02-01
影响因子：
--
通讯作者：
Howlett, Barbara J.
中科院分区：
文献类型：
--
作者：
Fox, Ellen M.;Howlett, Barbara J.
表聚硫代二氧代哌嗪（epipolithiodioxopiperazines，ETP）是一类仅由真菌产生的有毒次级代谢产物。最近的研究工作提供了深入了解这些化合物的毒性的分子机制。许多真菌的完整基因组序列的可用性也促进了推定的ETP生物合成基因簇的鉴定。表达和突变分析证实了这种基因簇在两种ETP，西罗结蛋白PL和胶毒素的生物合成中的作用。不能产生这些ETP的突变体的产生促进了这些分子作为致病性真菌与其宿主之间相互作用的毒力因子的评估。(C)2007年英国真菌学会。由爱思唯尔有限公司出版。保留所有权利。
Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi. Recent research efforts have provided insight into the molecular mechanisms of the toxicity of these compounds. The availability of complete genome sequences for many fungi has also facilitated the identification of putative ETP biosynthetic gene clusters. Expression and mutational analyses have confirmed the role of such gene clusters in the biosynthesis of two ETPs, sirodesmin PL and gliotoxin. The creation of mutants unable to produce these ETPs has facilitated the assessment of these molecules as virulence factors in interactions between pathogenic fungi and their hosts. (C) 2007 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.