SPECT IMAGING OF SEROTONIN(2) RECEPTORS IN DEPRESSION
SPECT IMAGING OF SEROTONIN(2) RECEPTORS IN DEPRESSION
复制标题
DOI：
10.1016/0925-4927(92)90018-y
复制
发表时间：
1992-12-01
影响因子：
2.3
通讯作者：
KAUFMAN, L
中科院分区：
文献类型：
--
作者：
DHAENEN, H;BOSSUYT, A;KAUFMAN, L
Changes of serotonin2 (5HT2) receptors have been described in depression, and long-term antidepressant treatment has been shown to decrease the number of 5HT2 receptors. In this study, single photon emission computed tomography (SPECT), with 2-I-123-ketanserin as a ligand, was used to investigate 5HT2 receptors in vivo in the brain of depressed patients and normal volunteers. A higher uptake of the tracer was observed in the parietal cortex of the patients, and there was a right greater than left asymmetry in the infero-frontal region of the depressed subjects and not in that of the control subjects. These findings could indicate changes in 5HT2 receptors in major depression.
