Prognostic Significance of Elevated Baseline Troponin in Patients With Acute Coronary Syndromes and Chronic Kidney Disease Treated With Different Antithrombotic Regimens A Substudy From the ACUITY Trial
Prognostic Significance of Elevated Baseline Troponin in Patients With Acute Coronary Syndromes and Chronic Kidney Disease Treated With Different Antithrombotic Regimens A Substudy From the ACUITY Trial
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DOI：
10.1161/circinterventions.111.963876
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发表时间：
2012-04-01
影响因子：
5.6
通讯作者：
Stone, Gregg W.
中科院分区：
文献类型：
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作者：
Acharji, Subasit;Baber, Usman;Stone, Gregg W.
急性冠状动脉综合征（ACS）患者基线心肌肌钙蛋白升高预示不良预后。肌钙蛋白升高在慢性肾脏病（CKD）和ACS患者的预后价值是不太确定的ACUITY（急性导管插入术和紧急干预分诊策略）trial，13 819例中度和高危ACS患者随机分配接受肝素加糖蛋白IIb/IIIa抑制剂（GPI），比伐卢定加GPI，或比伐卢定单药治疗。在2179例CKD患者中（肌酐清除率
Background-Elevation of baseline cardiac troponin in patients presenting with acute coronary syndromes (ACS) confers an adverse prognosis. The prognostic value of troponin elevation in patients with chronic kidney disease (CKD) and ACS is less certain.Methods and Results-In the ACUITY (Acute Catheterization and Urgent Intervention Triage strategy) trial, 13 819 patients with moderate and high-risk ACS were assigned randomly to receive heparin plus a glycoprotein IIb/IIIa inhibitor (GPI), bivalirudin plus a GPI, or bivalirudin monotherapy. Among 2179 patients with CKD (creatinine clearance