Perceived medication benefits and their association with interest in using inhaled insulin in type 2 diabetes: a model of patients' cognitive framework
Perceived medication benefits and their association with interest in using inhaled insulin in type 2 diabetes: a model of patients' cognitive framework
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DOI：
10.2147/ppa.s18799
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发表时间：
2011-01-01
影响因子：
2.2
通讯作者：
Rubin, Richard R.
中科院分区：
文献类型：
--
作者：
Peyrot, Mark;Rubin, Richard R.
目的：要检查预测患者感知的相关性不同的糖尿病药物治疗的好处，并确定如何吸入性胰岛素的药物治疗效益评级与评估，并在吸入insulin.Methods的兴趣：这项研究是一个互联网调查的美国样本（n = 1094）的成人2型糖尿病使用不同的药物治疗方案。向患者简要描述了本研究中所述吸入性胰岛素（基于MannKind Corporation的Technosphere胰岛素）的潜在临床获益和给药程序。测量指标包括药物获益、需求和相关性、获益评级和所研究的吸入性胰岛素相对于当前药物的总体评价以及对研究药物的兴趣。多变量回归评估显著（P <0.05）独立关联，控制人口统计学和疾病特征。结果：潜在药物益处（避免高血糖、低血糖、体重增加、不适/不便）的相关性与患者需求的客观和主观指标显著相关。大多数需求指标仅与其适用的具体利益相关;对体重和生活方式的关注与多种利益相关。评价的研究吸入性胰岛素，以避免餐后高血糖症和不适/不便与整体评价和兴趣的吸入性胰岛素在这项研究中描述的;评级这种药物，以避免体重增加与整体评价rates.Conclusions：相关性不同的潜在利益是基于客观和主观指标的需要。本研究中描述的吸入性胰岛素在避免餐后高血糖和不适/不便方面的感知疗效是与该药物的评价和兴趣最密切相关的获益。
Objective: To examine predictors of patient perceived relevance of different diabetes medication benefits, and to determine how medication benefit ratings of an inhaled insulin were associated with evaluation of, and interest in that inhaled insulin.Methods: The study was an Internet survey of a US sample (n = 1094) of adults with type 2 diabetes using different medication regimens. Patients were given a brief description of potential clinical benefits and administration procedures for the inhaled insulin described in this study (based on MannKind Corporation's Technosphere insulin). Measures included indicators of medication benefits, needs and relevance, benefit ratings and overall evaluation of the studied inhaled insulin relative to current medication, and interest in the study medication. Multivariate regression assessed significant (P < 0.05) independent associations, controlling for demographic and disease characteristics.Results: Relevance of potential medication benefits (avoidance of hyperglycemia, hypoglycemia, weight gain, discomfort/inconvenience) was significantly associated with objective and subjective indicators of patients' needs. Most need indicators were associated only with the specific benefit to which they apply; concerns about weight and lifestyle were associated with multiple benefits. Ratings of the studied inhaled insulin for avoiding postprandial hyperglycemia and discomfort/inconvenience were associated with overall evaluation of and interest in the inhaled insulin described in this study; rating of this medication for avoiding weight gain was associated with overall evaluation ratings.Conclusions: Relevance of different potential benefits was based on objective and subjective indicators of need. Perceived efficacy of the inhaled insulin described in this study for avoiding postprandial hyperglycemia and discomfort/ inconvenience were the benefits most strongly related to the evaluation of and interest in this medication.